Effect of dexmeditomidine on postoperative junctional ectopic tachycardia after complete surgical repair of tetralogy of Fallot: A prospective randomized controlled study.
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Date
2015-07
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Abstract
Introduction: Incidence of junctional ectopic tachycardia (JET) after repair of tetralogy of Fallot (TOF)
is 5.6–14%. Dexmeditomidine is a α-2 adrenoceptor agonist modulates the release of catecholamine,
resulting in bradycardia and hypotension. These effects are being explored as a therapeutic option for the
prevention of perioperative tachyarrhythmia. We undertook this study to examine possible preventive effects
of dexmedetomidine on postoperative JET and its impact on the duration of ventilation time and length
of Intensive Care Unit stay. Methods: After obtaining approval from the hospitals ethics committee and
written informed consent from parents, this quasi-randomized trial was initiated. Of 94 patients, 47 patients
received dexmedetomidine (dexmedetomidine group) and 47 patients did not receive the drug (control group).
Results: Dexmedetomidine group had more number of complex variants like TOF with an absent pulmonary
valve or pulmonary atresia (P = 0.041). Hematocrit on cardiopulmonary bypass (CPB), heart rate while coming
off from CPB and inotrope score was significantly low in the dexmedetomidine group compared to control
group. The incidence of JET was significantly low in dexmedetomidine group (P = 0.040) compared to control
group. Conclusions: Dexmedetomidine may have a potential benefit of preventing perioperative JET.
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Keywords
Dexmedetomidine, Junctional ectopic tachycardia, Tetralogy of Fallot
Citation
Kadam Shankar V, Tailor Kamlesh B, Kulkarni Snehal, Mohanty Smrutiranjan R, Joshi Preetha V, Rao Suresh G. Effect of dexmeditomidine on postoperative junctional ectopic tachycardia after complete surgical repair of tetralogy of Fallot: A prospective randomized controlled study. Annals of Cardiac Anaesthesia. 2015 Jul; 18(3): 323-328.