Predominance of DENV-3 among patients in Ouagadougou, Burkina Faso

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dc.contributor.authorOuattara, Abdoul Karimen_US
dc.contributor.authorToyin, Bello Shoukrat Ohuwaen_US
dc.contributor.authorOuédraogo, Alphonsineen_US
dc.contributor.authorTraoré, Lassinaen_US
dc.contributor.authorDjigma, Florencia Wendkuunien_US
dc.contributor.authorSimporé, Jacquesen_US
dc.date.accessioned2025-08-13T09:35:52Z
dc.date.available2025-08-13T09:35:52Z
dc.date.issued2025-03
dc.description.abstractBackground & objectives: Dengue is an emerging vector-borne viral disease in tropical and subtropical areas such as Burkina Faso that experienced dengue outbreak in, 2013, 2016, 2017 and more recently in 2023. This study aimed to determine the seroprevalence and dengue serotype in suspected patients in Ouagadougou, Burkina Faso. Methods: The study was conducted during October and November 2023 and included suspected febrile patients seen at HOSCO and CERBA. Plasma or serum samples were used for the detection of non-structural proteins (NS1) and IgM and IgG antibodies against the dengue virus using SD Bioline Dengue Duo rapid detection kit. Viral RNA was extracted using the QIAamp Viral RNA Mini Kit and dengue serotypes were determined by real-time RT-PCR using the Dengue Real-TM Genotype kit. Results: The study population consisted of 896 patients, including 397 (44.3%) men and 499 (55.7%) women. Dengue seroprevalence was 16.5% (148/896) with 14.1% (126/896) of patients positive for the NS1 antigen, 1.3% (12/896) positive for IgM, and 2.7% (24/896) positive for IgG. Serotyping among 40 out of 45 positive patients revealed 77.5% (31/40) DENV-3, 17.5% (7/40) DENV-1, and 5.0% (2/40) DENV-2. Interpretation & conclusion: The present study reports a high seroprevalence of dengue virus infection among patients during the months considered as the peak of infection in Burkina Faso. The results revealed a predominance of DENV-3. Continuous surveillance of dengue virus serotypes circulating in Burkina Faso is crucial.en_US
dc.identifier.affiliationsCentre de Recherche Biomoléculaire Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso; Université Norbert Zongo/Centre Universitaire de Manga, Koudougou, Burkina Faso; Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), Université Joseph KIZERBO, Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsCentre de Recherche Biomoléculaire Pietro Annigoni (CERBA), Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsLaboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), Université Joseph KIZERBO, Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsCentre de Recherche Biomoléculaire Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso; Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), Université Joseph KIZERBO, Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsCentre de Recherche Biomoléculaire Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso; Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), Université Joseph KIZERBO, Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsCentre de Recherche Biomoléculaire Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso; Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), Université Joseph KIZERBO, Ouagadougou, Burkina Fasoen_US
dc.identifier.citationOuattara Abdoul Karim, Toyin Bello Shoukrat Ohuwa, Ouédraogo Alphonsine, Traoré Lassina, Djigma Florencia Wendkuuni, Simporé Jacques. Predominance of DENV-3 among patients in Ouagadougou, Burkina Faso. Journal of Vector Borne Diseases . 2025 Mar; 62(1): 60-66en_US
dc.identifier.issn0972-9062
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/252567
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume62en_US
dc.source.urihttps://doi.org/0.4103/JVBD.JVBD_68_24https://creativecommons.org/licenses/by-nc-sa/4.0en_US
dc.subjectDengue virusen_US
dc.subjectSerotypesen_US
dc.subjectNS1en_US
dc.subjectIgMen_US
dc.subjectIgGen_US
dc.subjectBurkina Fasoen_US
dc.titlePredominance of DENV-3 among patients in Ouagadougou, Burkina Fasoen_US
dc.typeJournal Articleen_US
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