Effects of paraquat on anti-oxidant system in rats.
No Thumbnail Available
Date
2007-05-16
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The toxic effects of paraquat on the anti-oxidant defense system of male albino rats were evaluated, after administering either a single dose (1.5 and 7.5 mg/kg of body weight) or continuous daily doses (same as above, i.e., 1.5 mg/kg and 7.5 mg/kg of body weight) for 3 and 7 days. Glutathione levels in blood cells, liver, lung and kidney tissues decreased in a dose and time dependent manner. Glutathione reductase and glucose-6-phosphate dehydrogenase activity decreased, whereas the activity of glutathione-S-transferase, glutathione peroxidase, catalase and superoxide dismutase increased in paraquat exposure. Malondialdehyde formation also increased in a dose and time dependent manner. The alterations of anti-oxidant system particularly glutathione can be utilized as biomarkers during management of paraquat poisoning.
Description
Keywords
Citation
Ray S, Sengupta A, Ray A. Effects of paraquat on anti-oxidant system in rats. Indian Journal of Experimental Biology. 2007 May; 45(5): 432-8