INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD): Development and Validation.
dc.contributor.author | Juneja, Monica | |
dc.contributor.author | Mishra, Devendra | |
dc.contributor.author | Russell, Paul S S | |
dc.contributor.author | Gulati, Sheffali | |
dc.contributor.author | Deshmukh, Vaishali | |
dc.contributor.author | Tudu, Poma | |
dc.contributor.author | Sagar, Rajesh | |
dc.contributor.author | Silberberg, Donald | |
dc.contributor.author | Bhutani, Vinod K | |
dc.contributor.author | Pinto, Jennifer M | |
dc.contributor.author | Durkin, Maureen | |
dc.contributor.author | Pandey, Ravindra M | |
dc.contributor.author | Nair, M K C | |
dc.contributor.author | Arora, Narendra K | |
dc.contributor.other | INCLEN Study Group | en_US |
dc.date.accessioned | 2016-01-19T07:27:24Z | |
dc.date.available | 2016-01-19T07:27:24Z | |
dc.date.issued | 2014-05 | |
dc.description.abstract | Objective: To develop and validate INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD). Design: Diagnostic test evaluation by cross sectional design Setting: Four tertiary pediatric neurology centers in Delhi and Thiruvanthapuram, India. Methods: Children aged 2-9 years were enrolled in the study. INDT-ASD and Childhood Autism Rating Scale (CARS) were administered in a randomly decided sequence by trained psychologist, followed by an expert evaluation by DSM-IV TR diagnostic criteria (gold standard). Main outcome measures: Psychometric parameters of diagnostic accuracy, validity (construct, criterion and convergent) and internal consistency. Results: 154 children (110 boys, mean age 64.2 mo) were enrolled. The overall diagnostic accuracy (AUC=0.97, 95% CI 0.93, 0.99; P<0.001) and validity (sensitivity 98%, specificity 95%, positive predictive value 91%, negative predictive value 99%) of INDT-ASD for Autism spectrum disorder were high, taking expert diagnosis using DSM-IV-TR as gold standard. The concordance rate between the INDT-ASD and expert diagnosis for ‘ASD group’ was 82.52% [Cohen’s κ=0.89; 95% CI (0.82, 0.97); P=0.001]. The internal consistency of INDT-ASD was 0.96. The convergent validity with CARS (r = 0.73, P= 0.001) and divergent validity with Binet-Kamat Test of intelligence (r = -0.37; P=0.004) were significantly high. INDT-ASD has a 4-factor structure explaining 85.3% of the variance. Conclusion: INDT-ASD has high diagnostic accuracy, adequate content validity, good internal consistency high criterion validity and high to moderate convergent validity and 4-factor construct validity for diagnosis of Autistm spectrum disorder. | en_US |
dc.identifier.citation | Juneja Monica, Mishra Devendra, Russell Paul S S, Gulati Sheffali, Deshmukh Vaishali, Tudu Poma, Sagar Rajesh, Silberberg Donald, Bhutani Vinod K, Pinto Jennifer M, Durkin Maureen, Pandey Ravindra M, Nair M K C, Arora Narendra K. INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD): Development and Validation. Indian Pediatrics. 2014 May; 51(5): 359-365. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/170610 | |
dc.language.iso | en | en_US |
dc.source.uri | https://www.indianpediatrics.net/may2014/may-359-365.htm | en_US |
dc.subject | Childhood | en_US |
dc.subject | Neuro developmental disorders | en_US |
dc.subject | Resource limited settings | en_US |
dc.subject | Childhood austism rating scale | en_US |
dc.subject | Pervasive developmental disorders | en_US |
dc.title | INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD): Development and Validation. | en_US |
dc.type | Article | en_US |