INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD): Development and Validation.

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dc.contributor.authorJuneja, Monica
dc.contributor.authorMishra, Devendra
dc.contributor.authorRussell, Paul S S
dc.contributor.authorGulati, Sheffali
dc.contributor.authorDeshmukh, Vaishali
dc.contributor.authorTudu, Poma
dc.contributor.authorSagar, Rajesh
dc.contributor.authorSilberberg, Donald
dc.contributor.authorBhutani, Vinod K
dc.contributor.authorPinto, Jennifer M
dc.contributor.authorDurkin, Maureen
dc.contributor.authorPandey, Ravindra M
dc.contributor.authorNair, M K C
dc.contributor.authorArora, Narendra K
dc.contributor.otherINCLEN Study Groupen_US
dc.date.accessioned2016-01-19T07:27:24Z
dc.date.available2016-01-19T07:27:24Z
dc.date.issued2014-05
dc.description.abstractObjective: To develop and validate INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD). Design: Diagnostic test evaluation by cross sectional design Setting: Four tertiary pediatric neurology centers in Delhi and Thiruvanthapuram, India. Methods: Children aged 2-9 years were enrolled in the study. INDT-ASD and Childhood Autism Rating Scale (CARS) were administered in a randomly decided sequence by trained psychologist, followed by an expert evaluation by DSM-IV TR diagnostic criteria (gold standard). Main outcome measures: Psychometric parameters of diagnostic accuracy, validity (construct, criterion and convergent) and internal consistency. Results: 154 children (110 boys, mean age 64.2 mo) were enrolled. The overall diagnostic accuracy (AUC=0.97, 95% CI 0.93, 0.99; P<0.001) and validity (sensitivity 98%, specificity 95%, positive predictive value 91%, negative predictive value 99%) of INDT-ASD for Autism spectrum disorder were high, taking expert diagnosis using DSM-IV-TR as gold standard. The concordance rate between the INDT-ASD and expert diagnosis for ‘ASD group’ was 82.52% [Cohen’s κ=0.89; 95% CI (0.82, 0.97); P=0.001]. The internal consistency of INDT-ASD was 0.96. The convergent validity with CARS (r = 0.73, P= 0.001) and divergent validity with Binet-Kamat Test of intelligence (r = -0.37; P=0.004) were significantly high. INDT-ASD has a 4-factor structure explaining 85.3% of the variance. Conclusion: INDT-ASD has high diagnostic accuracy, adequate content validity, good internal consistency high criterion validity and high to moderate convergent validity and 4-factor construct validity for diagnosis of Autistm spectrum disorder.en_US
dc.identifier.citationJuneja Monica, Mishra Devendra, Russell Paul S S, Gulati Sheffali, Deshmukh Vaishali, Tudu Poma, Sagar Rajesh, Silberberg Donald, Bhutani Vinod K, Pinto Jennifer M, Durkin Maureen, Pandey Ravindra M, Nair M K C, Arora Narendra K. INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD): Development and Validation. Indian Pediatrics. 2014 May; 51(5): 359-365.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/170610
dc.language.isoenen_US
dc.source.urihttps://www.indianpediatrics.net/may2014/may-359-365.htmen_US
dc.subjectChildhooden_US
dc.subjectNeuro developmental disordersen_US
dc.subjectResource limited settingsen_US
dc.subjectChildhood austism rating scaleen_US
dc.subjectPervasive developmental disordersen_US
dc.titleINCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD): Development and Validation.en_US
dc.typeArticleen_US
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