INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD): Development and Validation.
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Date
2014-05
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Abstract
Objective: To develop and validate INCLEN Diagnostic Tool for
Autism Spectrum Disorder (INDT-ASD).
Design: Diagnostic test evaluation by cross sectional design
Setting: Four tertiary pediatric neurology centers in Delhi and
Thiruvanthapuram, India.
Methods: Children aged 2-9 years were enrolled in the study.
INDT-ASD and Childhood Autism Rating Scale (CARS) were
administered in a randomly decided sequence by trained
psychologist, followed by an expert evaluation by DSM-IV TR
diagnostic criteria (gold standard).
Main outcome measures: Psychometric parameters of
diagnostic accuracy, validity (construct, criterion and convergent)
and internal consistency.
Results: 154 children (110 boys, mean age 64.2 mo) were
enrolled. The overall diagnostic accuracy (AUC=0.97, 95% CI
0.93, 0.99; P<0.001) and validity (sensitivity 98%, specificity 95%,
positive predictive value 91%, negative predictive value 99%) of
INDT-ASD for Autism spectrum disorder were high, taking expert
diagnosis using DSM-IV-TR as gold standard. The concordance
rate between the INDT-ASD and expert diagnosis for ‘ASD group’
was 82.52% [Cohen’s κ=0.89; 95% CI (0.82, 0.97); P=0.001]. The
internal consistency of INDT-ASD was 0.96. The convergent
validity with CARS (r = 0.73, P= 0.001) and divergent validity with
Binet-Kamat Test of intelligence (r = -0.37; P=0.004) were
significantly high. INDT-ASD has a 4-factor structure explaining
85.3% of the variance.
Conclusion: INDT-ASD has high diagnostic accuracy, adequate
content validity, good internal consistency high criterion validity
and high to moderate convergent validity and 4-factor construct
validity for diagnosis of Autistm spectrum disorder.
Description
Keywords
Childhood, Neuro developmental disorders, Resource limited settings, Childhood austism rating scale, Pervasive developmental disorders
Citation
Juneja Monica, Mishra Devendra, Russell Paul S S, Gulati Sheffali, Deshmukh Vaishali, Tudu Poma, Sagar Rajesh, Silberberg Donald, Bhutani Vinod K, Pinto Jennifer M, Durkin Maureen, Pandey Ravindra M, Nair M K C, Arora Narendra K. INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD): Development and Validation. Indian Pediatrics. 2014 May; 51(5): 359-365.