Hepatoprotective activity of ethanol extract of Pavetta Indica Linn leaves

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dc.contributor.authorValte, Varkungen_US
dc.contributor.authorSingh, M. Premchanden_US
dc.contributor.authorRaleng, Indiraen_US
dc.contributor.authorR. K., Losicaen_US
dc.date.accessioned2020-04-23T07:49:34Z
dc.date.available2020-04-23T07:49:34Z
dc.date.issued2018-05
dc.description.abstractBackground: Traditionally, the bark of Pavetta Indica Linn., in decoction or pulverized, is administered, especially to children, to correct visceral obstructions. The decocted leaves are used externally to alleviate the pains caused by hemorrhoids. The root, pulverized and mixed with the ginger and rice-water, is given in dropsy. A local fomentation with the leaves is useful in relieving the pain of piles. Paracetamol (PCM) toxicity generates free radicals and raised serum enzyme levels-SGPT, SGOT, Alkaline Phosphatase and S. Albumin. It causes necrosis, congested vessels, multifocal area of fatty changes nuclear disintegration, sinusoidal dilation, kuffer cell hyperplasia. The reverse is considered as the index of hepatoprotective activity. The present study is being taken up to screen hepatoprotective action of P. Indica Linn.Methods: The acute liver damage in albino rats was induced by per oral administration of a single dose of 2000mg/kg b.w. PCM suspension in 0.5% Carboxy methyl cellulose (CMC) and chronic liver damage by giving the same dose of PCM on the 7th day. The hepatoprotective activity was monitored biochemically by estimating S. transaminase, S. bilirubin and S. Protein on the 8th day of experiment.Results: Ethanol extract of P. Indica inhibited PCM induced liver toxicity in albino rats at 100mg/kg and 200mg/kg b.w as assessed by the biochemical values.Conclusions: Ethanol extract of “P. Indica” exhibited significant hepatoprotective activity.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Jawaharlal Nehru Institute of Medical Sciences, Porompat, Imphal, Manipur, Indiaen_US
dc.identifier.citationValte Varkung, Singh M. Premchand, Raleng Indira, R. K. Losica. Hepatoprotective activity of ethanol extract of Pavetta Indica Linn leaves. International Journal of Basic & Clinical Pharmacology. 2018 May; 7(5): 1006-1010en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199695
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber5en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20181651en_US
dc.subjectCarboxy methyl celluloseen_US
dc.subjectEthanolen_US
dc.subjectFlavonoidsen_US
dc.subjectHepatoprotective activityen_US
dc.subjectPavetta Indica Linnen_US
dc.subjectParacetamolen_US
dc.subjectSilymarinen_US
dc.titleHepatoprotective activity of ethanol extract of Pavetta Indica Linn leavesen_US
dc.typeJournal Articleen_US
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