Catechin, an active constituent of green tea, preserves skeletal muscle activity in dexamethasone induced cachexia by increasing acetylcholine sensitivity in muscles of Wistar rats

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dc.contributor.authorSaimithra, Thammeraen_US
dc.contributor.authorKumar, Niteshen_US
dc.contributor.authorNandakumar, Krishnadasen_US
dc.contributor.authorNampoothiri, Madhavanen_US
dc.contributor.authorRao, C Mallikarjunaen_US
dc.date.accessioned2020-01-02T06:32:13Z
dc.date.available2020-01-02T06:32:13Z
dc.date.issued2018-05
dc.description.abstractChronic administration of glucocorticoids produces cachexia like symptoms such as muscular dystrophy, weight loss and skeletal muscle dysfunction. However, only limited options are available for treatment of this disease. One of the tea catechins, epigallocatechin-3-gallate attenuated skeletal muscle atrophy in cancer cachexia. In this context, we explored here (+)-catechin hydrate (catechin) for of its anticachectic activity in dexamethasone induced muscle dystrophy. Dosing of catechin at 100 mg/kg p.o. was continued for 5 days along with a daily dosing of dexamethasone at 0.6 mg/kg i.p. On the 6th day, animals were assessed for cachectic condition using changes in body weight, functional aspect of skeletal muscle such as muscle integrity, locomotor activity, handgrip strength, glucose uptake, responsiveness of skeletal muscle to acetylcholine, by estimating inflammatory parameters such as nitrite, myeloperoxidase in the gastrocnemius muscle and by evaluating plasma biochemical parameters such as triglycerides, total protein, albumin, creatinine, urea and IL-6 levels. Except for a few parameters, such as body weight, glucose uptake by hemi-diaphragm and triglyceride level, remaining parameters were significantly reversed by catechin treatment. The underlying mechanism of the myoprotective action of catechin has been postulated by the increased sensitivity of muscle to acetylcholine as demonstrated in this study, which might be responsible for prevention of muscle inflammation.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka-576 104, Indiaen_US
dc.identifier.citationSaimithra Thammera, Kumar Nitesh, Nandakumar Krishnadas, Nampoothiri Madhavan, Rao C Mallikarjuna. Complete genome sequence analyses of an Indian cattle strain of bovine viral diarrhoea virus 2 (BVDV-2). Indian Journal of Experimental Biology. 2018 May; 56(5): 322-326en_US
dc.identifier.issn0975-1009
dc.identifier.issn0019-5189
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/190942
dc.languageenen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.relation.issuenumber5en_US
dc.relation.volume56en_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/44283en_US
dc.titleCatechin, an active constituent of green tea, preserves skeletal muscle activity in dexamethasone induced cachexia by increasing acetylcholine sensitivity in muscles of Wistar ratsen_US
dc.typeJournal Articleen_US
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