Evaluation of the effects of donepezil in psychotic disorders using Swiss albino mice

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dc.contributor.authorTanwani, Hemanten_US
dc.contributor.authorChurihar, Riteshen_US
dc.contributor.authorPandit, Sameeren_US
dc.date.accessioned2020-04-23T08:01:42Z
dc.date.available2020-04-23T08:01:42Z
dc.date.issued2020-04
dc.description.abstractBackground: Schizophrenia as a psychotic disorder is currently treated by various antipsychotic drugs. A large group of patients still remain resistant to the treatment and present in the form of residual cognitive deficits. Donepezil has been advocated at various conferences and seminars for using it in schizophrenia patients. Donepezil is currently approved drug for Alzheimer's disease to improve cognition. Hence, we have tried to assess its role for psychotic models induced by methylphenidate in mice.Methods: Methylphenidate 5 mg/kg was given by intraperitoneal (i.p) route to induce psychosis in Swiss albino mice (n=6). Donepezil was given alone in a dose of 1 mg/kg and in combination with low dose haloperidol 0.1 mg/kg and groups were compared with haloperidol 0.2 mg/kg. Activity of donepezil was also assessed on the haloperidol induced catalepsy test. Statistical analysis was done with ANOVA followed by Bonferroni抯 test.Results: Methylphenidate successfully induced characteristic stereotypy behaviour in mice similar to amphetamine. Both donepezil 1 mg/kg and haloperidol 0.2 mg/kg showed significant reduction in stereotypy behaviour and there was no statistically significant difference between the two (p<0.05). Effects with donepezil were only slightly inferior to standard while it抯 combination (1 mg/kg with haloperidol 0.1 mg/kg) showed comparable results with the standard haloperidol. Donepezil had only marginally enhanced potential to induce catatonia which was statistically insignificant (p>0.05).Conclusions: Methylphenidate can be used successfully to induce psychosis in animals and donepezil may be a promising and potentially useful drug as add on therapy to routine antipsychotics.en_US
dc.identifier.affiliationsDepartment of Pharmacology, MGM Medical College, Indore, Madhya Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Govt. Medical College, Ratlam, Madhya Pradesh, Indiaen_US
dc.identifier.citationTanwani Hemant, Churihar Ritesh, Pandit Sameer. Evaluation of the effects of donepezil in psychotic disorders using Swiss albino mice. International Journal of Basic & Clinical Pharmacology. 2020 Apr; 9(4): 533-537en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200595
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20201051en_US
dc.subjectDonepezilen_US
dc.subjectMethylphenidateen_US
dc.subjectHaloperidolen_US
dc.subjectStereotypyen_US
dc.subjectAlbino miceen_US
dc.titleEvaluation of the effects of donepezil in psychotic disorders using Swiss albino miceen_US
dc.typeJournal Articleen_US
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