Neuropharmacological studies on Fusarium toxins-III: Neurochemical investigations on total toxin extracts from F. moniliforme and F. oxysporum.

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dc.contributor.authorGanguli, Sen_US
dc.contributor.authorHota, Den_US
dc.contributor.authorGoel, R Ken_US
dc.contributor.authorAcharya, S Ben_US
dc.contributor.authorBhattacharya, S Ken_US
dc.date.accessioned2009-05-28T12:30:38Z
dc.date.available2009-05-28T12:30:38Z
dc.date.issued1996-06-01en_US
dc.description.abstractNeurochemical effects of different fusarial toxins elaborated from F. moniliforme (FM) and F. oxysporum (FO) were investigated. FM showed significant nonspecific and irreversible monoamine oxidase (MAO) inhibition which was qualitatively comparable to that induced by nialamide, a nonselective MAO inhibitor. FO did not exhibit any significant MAO inhibitory effect. FM produced a dose related increase in monoamine concentrations (dopamine, noradrenaline and 5-hydroxytryptamine) in different rat brain areas namely, diencephalon-midbrain, caudate nucleus and pons-medulla. FO, on the contrary, produced marked increase in dopamine concentration in the caudate nucleus with concomitant reduction in noradrenaline levels in diencephalon-midbrain and pons-medulla with little effect on 5-HT concentration. The neurochemical effects of FM and FO are consonant with the earlier reports on the neuropharmacological profile of these toxins. Thus, FM was reported to have nialamide like activity, whereas FO actions were dopaminergic in nature.en_US
dc.description.affiliationDepartment of Pharmacology, Banaras Hindu University, Varanasi, India.en_US
dc.identifier.citationGanguli S, Hota D, Goel RK, Acharya SB, Bhattacharya SK. Neuropharmacological studies on Fusarium toxins-III: Neurochemical investigations on total toxin extracts from F. moniliforme and F. oxysporum. Indian Journal of Experimental Biology. 1996 Jun; 34(6): 531-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58179
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshFusarium --chemistryen_US
dc.subject.meshMonoamine Oxidase Inhibitors --pharmacologyen_US
dc.subject.meshMycotoxins --pharmacologyen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.titleNeuropharmacological studies on Fusarium toxins-III: Neurochemical investigations on total toxin extracts from F. moniliforme and F. oxysporum.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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