Effect of vanadate on tryptophan metabolism in streptozotocin diabetic rats.

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Date
1992-12-01
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Abstract
Administration of sodium orthovanadate (0.3 mg/ml) through drinking water for 20 days to streptozotocin-induced diabetic rats resulted in reversal of markedly elevated activities of some of the key enzymes of tryptophan-niacin pathway, viz. hepatic and renal aminocarboxymuconate semialdehyde decarboxylase and hepatic tryptophan oxygenase, to normal levels without restoring the elevated blood sugar level to normal state. However vanadate administration to normal rats did not cause any significant change.
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Pandharpurkar S, Shastri NV. Effect of vanadate on tryptophan metabolism in streptozotocin diabetic rats. Indian Journal of Biochemistry & Biophysics. 1992 Dec; 29(6): 519-21
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https://imsear.searo.who.int/handle/123456789/26831
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Indian Journal of Biochemistry & Biophysics