Clinical and Surgical Management for Cerebral Astrocytoma
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Date
2024-11
Journal Title
Journal ISSN
Volume Title
Publisher
Society for Health Care & Research Development
Abstract
Cerebral astrocytoma is a primary brain tumor originating from astrocytes, the star- shaped glial cells that support and protect neurons. It represents a diverse group of tumors with varying degrees of malignancy, classified according to the World Health Organization (WHO) grading system into grades I through IV. Grade I astrocytomas, such as pilocytic astrocytomas, are generally well- circumscribed and less aggressive, while higher-grade tumors like anaplastic astrocytomas (Grade III) and glioblastoma multiforme (Grade IV) exhibit more aggressive behavior and poorer prognoses. Clinical presentation varies with tumor location and grade but commonly includes headaches, seizures, and focal neurological deficits. Diagnostic evaluation typically involves imaging techniques such as MRI and may be supplemented by biopsy for histological confirmation. Treatment strategies are tailored to the tumor grade and include surgical resection, radiation therapy, and chemotherapy. Despite advances in therapeutic approaches, the prognosis remains variable, with higher-grade tumors generally associated with reduced survival rates. Ongoing research focuses on improving early detection, understanding molecular mechanisms, and developing targeted therapies to enhance patient outcomes.
Description
Keywords
Cerebral astrocytoma, medical treatment, surgical intervention
Citation
Awar Omar Al, Zeki Layal Abou, Haddad Marwan, Nahle Zeinab, Nehme Patricia, Jabbour Caroline Samaha . Clinical and Surgical Management for Cerebral Astrocytoma. Annals of International Medical and Dental Research. 2024 Nov; 10(6): 12-19