Chandipura virus infection causing encephalitis in a tribal population of Odisha in eastern India.
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Date
2015-07
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Abstract
Background. The sudden death of 10 children in a tribal
village of Kandhamal district, Odisha in eastern India led to this
investigation.
Methods. We conducted a door-to-door survey to identify
cases. Antibodies for Chandipura, Japanese encephalitis, dengue,
chikungunya and West Nile viruses were tested by ELISA in
probable cases. Chandipura virus RNA was tested from both
human blood samples and sand flies by reverse transcriptase
polymerase chain reaction. We conducted vector surveys in
domestic and peridomestic areas, and collected sand flies.
Results. Entomological investigations revealed the presence
of Phlebotomus argentipes and Sergentomiya sp. Thirty-five
patients presented with fever, 12 of them had altered sensorium
including 4 who had convulsions. The blood samples of 21
patients were tested; four samples revealed Chandipura virusspecific
IgM antibody.
Conclusion. Chandipura virus infection causing encephalitis
affected this tribal population in eastern India at 1212 m above
sea level.
Natl Med J India 2015;28:185–7
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Dwibedi Bhagirathi, Sabat Jyotsnamayee, Hazra Rupenangshu K., Kumar Anu, Dinesh Diwakar Singh, Kar Shantanu K. Chandipura virus infection causing encephalitis in a tribal population of Odisha in eastern India. National Medical Journal of India. 2015 Jul-Aug; 28(4):185-188.