Tamsulosin vs Naftopidil in Medical Expulsive Therapy for Ureteral Stones — A Randomized Controlled Study.
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Date
2015-05
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Abstract
The aim of the present study was to compare the
efficacy of naftopidil and tamsulosin in the management
of ureteral stones. A total of 92 patients with symptomatic,
single < 10 mm ureteral stone, were enrolled in a prospective
study and randomized into two groups. Group 1, received
0.4 mg tamsulosin daily, whereas Group 2, received 50 mg
naftopidil daily. Patients were followed –up for up to 6
weeks. The primary end point was stone expulsion rate
and secondary end points were stone expulsion time , the
rate of interventions such as uretero-renoscopy, ureteric
stenting and extracorporeal shock wave lithotripsy and side
effects. There were no significant differences between the
groups with respect to age, sex, stone size and location.
Stone expulsion rate were 76% and 56% in the tamsulosin
and naftopidil group respectively. No significant difference
in the stone expulsion time and the rate of interventions
between the two groups. The finding suggest that tamsulosin
is superior to naftopidil for stone expulsion therapy.
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Devi N. Meena, Devi P. Shyamasakhi, Devi M. Medhabati, Devi Kh. Krishnapramodini, Singh Ak. Kaku, Tamsulosin vs Naftopidil in Medical Expulsive Therapy for Ureteral Stones — A Randomized Controlled Study. Indian Medical Gazette. 2015 May; 149(5): 187- 189.