Does Hepatocyte Paraffin 1 expression stand a role in determining the site origin of an adenocarcinoma from unknown gastrointestinal primary.
Loading...
Date
2016-10
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: Hepatocyte Paraffin 1 (Hep Par 1) was being extensively used to
recognize the hepatocellular carcinomas, until recognition of its expression in
tumors without hepatocellular differentiation. Aims and Objectives: The aim of
this study was to analyze if Hep Par 1 stain can serve as a specific marker of the
small intestinal (SI) adenocarcinomas, versus other gastrointestinal tract (GIT)
primary tumors. Materials and Methods: In this retrospective cross‑sectional
study, normal GIT mucosa (n ‑ 60), corresponding adenocarcinomas (n ‑ 60)
and nodal metastatic foci (n ‑ 60) from the same patients, including 10 cases
each from the esophagus, stomach, SI periampullary region, colon, rectum,
and gall bladder were included. H‑score was calculated by multiplying the stain
distribution and intensity scores. The H‑scores were compared with other clinical
and histological parameters. Results: While normal SI mucosa showed diffuse
strong Hep Par 1 staining, normal esophageal and gastric epitheliums were
negative and normal colon, rectal, and biliary epithelium showed weak focal
positivity. Adenocarcinomas from all these sites, however, showed Hep Par 1
expression, irrespective of the tumor type, site or origin, and tumor stage. The
corresponding metastatic sites also showed variable Hep Par 1 positivity, without
any site specificity. Conclusion: Hep Par 1 stain cannot help to determine the
exact site of origin of primary GIT tumors. Its expression in adenocarcinomas
across the GIT and their metastatic foci proves that it cannot be regarded as a
marker of SI differentiation, especially in malignancy.
Description
Keywords
Gastrointestinal tract adenocarcinomas, Hepatocyte Paraffin 1, immunohistochemical panel, normal gastrointestinal mucosa, unknown gastrointestinal primary
Citation
Yadav Rajni, Chopra Saurav, Garg Aayushi, Gupta Brijnandan, Kinra Prateek, Gupta Siddhartha Datta, Das Prasenjit. Does Hepatocyte Paraffin 1 expression stand a role in determining the site origin of an adenocarcinoma from unknown gastrointestinal primary. Indian Journal of Pathology & Microbiology. 2016 Oct-Dec 59(4): 474-480.