Anticoagulants in dermatology.
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Date
2016-11
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Abstract
Anticoagulants are the cornerstone of treatment of venous thromboembolism associated
with various medical conditions and surgical procedures. They act on different steps of the
coagulation pathway and are broadly categorized into heparins, vitamin K antagonists, and
inhibitors of thrombin and factor Xa. The classification is evolving as newer and better oral
and parenteral anticoagulants are being added. Anticoagulants in dermatology are important
not only for their therapeutic application in cutaneous thrombotic dermatoses such as livedoid
vasculitis, purpura fulminans, superficial and deep venous thrombosis and others but also
for their use in non‑thrombotic dermatoses such as lichen planus, recurrent oral aphthosis,
chronic urticaria and several others. Further, the use of anticoagulants for any indication is
associated with various adverse effects with dermatologic manifestations including specific
reactions such as warfarin‑induced skin necrosis, heparin‑induced thrombocytopenia and
anticoagulant‑associated cholesterol embolization syndrome.
Description
Keywords
Heparin, heparin‑induced thrombocytopenia, non‑vitamin K oral anticoagulants, warfarin, warfarin‑induced skin necrosis
Citation
Adya Keshavmurthy A, Inamadar Arun C, Palit Aparna. Anticoagulants in dermatology. Indian Journal of Dermatology, Venereology and Leprology. 2016 Nov-Dec; 82(6): 626-640.