Type III collagen disorders: A case report and review of literature.
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Date
2016-01
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Abstract
Collagen type III is a normal component of interstitium and blood vessels.
Collagenofibrotic glomerulopathy (CG) and nail patella syndrome (NPS) are
the diseases of abnormal type III collagen deposition. In spite of these curved
frayed structures with a periodicity of 45–60 nm are deposited in subendothelium
and mesangium in CG, they are found only in the basement membrane in NPS.
The clinical features of CG are confined to the kidney, NPS has associated
extra‑renal manifestations. Electron microscopy is essential to make the renal
diagnosis in both these rare diseases. Both the entities considered to be systemic
diseases evidence to suggest similar deposition in other organs, understanding
etiopathogenesis and disease progression await research.
Description
Keywords
Collagen type III, collagenofibrotic glomerulopathy, electron microscopy, nail patella syndrome, renal replacement therapy
Citation
Anitha A, Vankalakunti Mahesha, Siddini Vishwanath, Babu Kishore, Bonu Ravishankar, Ballal Sudarshan. Type III collagen disorders: A case report and review of literature. Indian Journal of Pathology & Microbiology. 2016 Jan-Mar 59(1): 75-77.