Evaluation of anti-arthritic potential of the methanolic extract of the aerial parts of Costus speciosus.
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Date
2012-10
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Abstract
Objective: Costus speciosus Koen. (Keu, Crape ginger), an ornamental plant, widely distributed in India is traditionally
used as astringent, aphrodisiac, purgative, anthelmintic, depurative, febrifuge and expectorant. The plant is also used in
rheumatism, dropsy, urinary diseases and jaundice. The purpose of this study is to evaluate the anti-arthritic activity of the
methanolic extract of the aerial parts of Costus speciosus (CS) in experimental animal models. Materials and Methods: The
powdered drug was subjected to successive solvent extraction, with solvents in increasing order of polarity to obtain the
methanolic extract of the aerial parts of the plant. CS was evaluated for anti-arthritic action by Freund’s adjuvant induced
arthritis test in adult Albino rats (150-200 gm). Rats were injected 0.1 ml of complete Freund’s adjuvant into the planter
region of the left hind paw. Statistical analysis was performed using One way analysis of variance (ANOVA) followed
by Bonferonni test. P<0.05 was considered statistically significant. Results: The methanolic extract of CS in doses of
400 and 800 mg/kg showed 75.50% and 68.33% protection against increase in paw edema, respectively. CS showed
dose-dependent action in all the experimental models. Conclusion: The present study indicates that CS has significant
anti-arthritic properties.
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Keywords
Arthritis, Costus speciosus, diclofenac sodium, Freund’s complete adjuvant, paw volume
Citation
Srivastava Shruti, Singh Pradeep, Jha Keshri K, Mishra Garima, Srivastava Sourabh, Khosa Ratan L. Evaluation of anti-arthritic potential of the methanolic extract of the aerial parts of Costus speciosus. Journal of Ayurveda and Integrative Medicine. 2012 Oct-Dec; 3(4): 204-208.