Admission Serum Uric Acid Levels and In-Hospital Outcomes in Patients with Acute Coronary Syndrome.
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Date
2015-01
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Abstract
Background: Uric acid is an independent risk factor for cardiovascular disease. Hospital
admission for ischemic heart disease (IHD) is increasing rapidly in our country. Although studies
were conducted abroad regarding association of serum uric acid with in-hospital outcomes in
patients with acute coronary syndrome (ACS), no data is yet available to show the association in
our country. Objective: The objective of this study was to assess the association of serum uric acid
level on admission with in-hospital outcomes of the patients with ACS. Materials and Methods:
This cross sectional comparative study was done in the Department of Cardiology, Dhaka Medical
College Hospital (DMCH) from January to December 2012. After proper ethical consideration
total 93 ACS patients were enrolled in the study by nonrandom sampling. Serum uric acid of all
subjects was measured within 24 hours of admission. Then in-hospital outcomes were observed in
all subjects. Results: The frequency of hyperuricemia among ACS patients was 24.7% (22.54% in
male and 31.82% in female). Hyperuricemic patients significantly developed heart failure (30.4%
vs 11.4%, p=0.032) and conduction defect (13.0% vs 1.4%, p=0.017) than normouricemic
subjects. The mean ejection fraction was significantly lower in hyperuricemic patients than
patients with normal uric acid level (50.87 ± 10.27% vs 55.94 ± 6.66%). The mean ± SD duration
of hospital stay of hyperuricemic group was significantly longer in patients with ACS (8.26 ± 1.18
vs 7.51±1.18 days, p=0.010). Conclusion: The measurement of serum uric acid level, an easily
available and inexpensive biochemical tool, might turn out as a valuable risk marker for prediction
of in-hospital outcomes in patients with ACS.
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Keywords
Serum uric acid, Ischemic heart disease, Acute coronary syndrome, Heart failure
Citation
Abdullah Abu Sadique, Begum Noortaj, Khan Md Aminul Haque, Hossain Mofazzal, Kabir Shah Mohd Eftar Jahan, Alam Mohammad Sarwar, Chowdhury Abdul Wadud, Khan H I Lutfur Rahman. Admission Serum Uric Acid Levels and In-Hospital Outcomes in Patients with Acute Coronary Syndrome. Journal of Enam Medical College. 2015 Jan; 5(1): 15-22.