Histopathological Evaluation of Lymph Node Biopsies: A Hospital Based Study.
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Date
2012-01
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Abstract
Background: Lymphadenopathy is a common manifestation of a large variety of disorders,
both benign and malignant. It is essential to define the pattern of disorders presenting
primarily as lymph node enlargement in a particular environment. Histopathological
examination of the lymph node biopsies is a gold standard test in the distinction between
reactive and malignant lymphoid proliferations as well as for detailed subtyping of
lymphomas. We designed this study in our population for histopathological evaluation of
lymph nodes that might be helpful for clinical management of these lesions. Objective:
Histopathological evaluation of lymphadenopathy from excised specimen, in relation to age
and sex of the patients, and distribution of the lymph nodes. Materials and Methods: It was a
retrospective cross sectional study conducted in the department of Pathology, Enam Medical
College & Hospital, Savar, Dhaka during the period from January 2006 to December 2010.
Lymph node biopsies of all patients of both sexes and all age groups were included.
Metastatic lymph nodes associated with evidence of primaries elsewhere in the body were
excluded from the study. Total 191 lymph node biopsies were selected for histopathological
evaluation. Among these 90 (47.12%) were from males and 101 (52.88%) were from females
with male to female ratio being 1:2.1. The age of the patients ranged from 2 to 85 years with
a mean age of 35.73 ± 18 years. Results: Cervical lymph nodes were the most common (56%)
biopsied group. Of the 191 cases 59 cases (30.89%) were reactive lymphadenitis, 64 cases
(33.5%) were tuberculosis, 2 cases (1.05%) were non-caseous granuloma, 11 cases (5.76%)
were Hodgkin lymphoma, 22 cases (11.52%) were non-Hodgkin lymphoma, 24 cases
(12.57%) were metastatic neoplasm and 9 cases (4.7%) were other lesions. Conclusion:
Tuberculosis was the most common cause of lymphadenopathy, followed by reactive
lymphadenitis and the cervical group of lymph nodes was most frequently affected.
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Keywords
Tuberculosis, Hodgkin lymphoma, Non-Hodgkin lymphoma, Metastatic neoplasm
Citation
Rahman Md Atiqur, Biswas Md Mamun Ali, Siddika Syeda Tasfia, Sikder Abdul Mannan. Histopathological Evaluation of Lymph Node Biopsies: A Hospital Based Study. Journal of Enam Medical College. 2012 Jan; 2(1): 8-14.