Clinico-Radiological Correlation in Childhood Hypopituitarism.
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Date
2010-07
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Abstract
Non-tumor etiology constitutes a major group of childhood hypopituitarism.
Magnetic resonance imaging has enormously complimented hormonal
assessment in these patients. We describe clinico-radiological correlates in thirtyone
children (23 boys), aged 1-17 years with a peak GH (growth hormone) levels
<7 ng/mL after pharmacological stimuli. Hypoplastic pituitary gland was the most
frequent abnormality in children with isolated growth hormone deficiency (IGHD)
as compared to stalk abnormalities in children with multiple pituitary hormone
deficiencies. MRI tetrad (hypoplastic/absent pituitary, hypoplastic stalk, absent/
ectopic posterior pituitary bright spot and empty sella) was more prevalent in IGHD.
MRI abnormalities correlated with the severity of growth hormone deficiency.
Description
Keywords
Child, Growth hormone deficiency, Hypopituitarism, MRI, Pituitary, hypoplasia
Citation
Dutta Pinaki, Bhansali Anil, Singh Paramjeet, Rajput Rajesh, Bhadada Sanjay. Clinico-Radiological Correlation in Childhood Hypopituitarism. Indian Pediatrics. 2010 July; 47(7): 615-618.