Crinum zeylanicum memory enhancing effect is mediated via central cholinergic transmission system.
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Date
2015-09
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Abstract
Background: Crinum zeylanicum is widely used in the ethno-therapeutic management
of folk management of epilepsy, pain, neuropsychiatric, and dementing disorders
in Nigeria. The current study was carried out to evaluate the possible mechanism
of the memory enhancing the effect of C. zeylanicum extract and alkaloidal rich
fraction in Wistar rats.
Methods: The effect of Crinum zeylanicum bulb extract (250, 500, and 1000 mg/kg
body weight orally), alkaloidal rich fraction (10, 20, and 40 mg/kg body weight p.o.),
normal saline (10 ml/kg orally), or Eserine (0.3 mg/kg body weight i.p.) on spatial
memory in rats was evaluated using the Y-maze. The blood samples obtained from
rats in all treatment groups were evaluated for cholinesterase activities using modified
Michelle electrometric method.
Results: The extract and the alkaloid significantly (p<0.05) and dose-dependently
increased spontaneous alternation behavior of rats in Y-maze. The extract produced
20.00%, 35.55%, and 52.00% inhibition of cholinesterase activity in the blood at
250, 500, and 1000 mg/kg body weight, respectively. The alkaloid produced 56.67%,
62.67%, and 68.67% inhibition of cholinesterase activity in blood at 10, 20, and
40 mg/kg body weight (p.o.). Eserine a standard cholinesterase inhibitor at 0.3 mg/kg
body weight produced a significant increase in spontaneous alternation behavior and
produced 73.33% inhibition of blood cholinesterase activity. Data obtained from the
study showed that the enhanced spontaneous alternation behavior observed in rats
treated with the extract, and the alkaloid may be due to facilitation of cholinergic
transmission resulting from inhibition of cholinesterase activity.
Conclusion: The extract, as well as its partially purified alkaloid, possesses potential
that may be employed for therapeutic management of Alzheimer’s disease.
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Keywords
Azheimer’s disease, Cholinesterase activity, Blood, Brain homogenate, Y-maze
Citation
Yahaya Tijani Adeniyi, Itohan Aboh Mercy, Ameh Fidelis Solomon, Adeola Salawu Oluwakanyinsola. Crinum zeylanicum memory enhancing effect is mediated via central cholinergic transmission system. International Journal of Basic & Clinical Pharmacology. 2015 Sep-Oct; 4(5): 864-868.