International Journal of Scientific Reports

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https://imsear.searo.who.int/handle/123456789/162466

Editor: Dr. Bhaven Kataria
ISSN: (Print) 2454-2156 (Online) 2454-2164

Frequency: Quarterly

Language: English

Open Access Peer-reviewed journal

Web site: https://www.sci-rep.com

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Now showing 1 - 20 of 293

Investigating the therapeutic potential of venom-derived compounds for the management of Alzheimer's disease: a comprehensive review
(Medip Academy, 2024-09) Aimen; Gul, MH; Sohail, R; Pahwani, R; Siddiqui, AR; Nadeem, S; Wardak, AB; Nazir, H; Ahmad, S; Ahmed, A.
Alzheimer’s disease is a comprehensive clinical syndrome featuring cognitive, emotional, and volitional function deterioration. Treatment strategies for Alzheimer's disease involve a mix of pharmacological and non-pharmacological approaches. Current treatments focus on palliative care with limited impact on the disease course. Venom-derived substances, known for their neuroactive properties, have emerged as a novel approach to Alzheimer's treatment. Our team conducted a thorough search for electronic literature related to therapeutic venom-derived substances efficacy in Alzheimer’s disease in different databases, including Medline, PubMed, Google Scholar, and Psych INFO, up to May 2024. In this article, the therapeutic effects of various venom-derived substances effects in Alzheimer’s disease are discussed. Various substances grant anti-inflammatory and anti-oxidant effects. The clinical application of venom-derived therapy is still a long way ahead, still, researchers believe that the ongoing work will eventually allow its compounds to be considered definitive candidates in various therapies in upcoming years.
Wormball as a cause of acute intestinal obstruction: a case report and brief review
(Medip Academy, 2024-12) Agrawal, H; Kumar, V; Tanwar, H; Maurya, SK; Kumar, S.
Soil transmitted helminthic (STHs) infection are mainly caused by Ascaris lumbricoides (AL) and commonly affect children worldwide and in India by ingestion of embryonated larva. It can cause various gastrointestinal and hepatobiliary complications. We are presenting a case of 25 years old gentleman who presented to emergency department with feature of intestinal obstruction. Patient was subsequently undergoing emergency exploratory laparotomy and obstructing worms were recovered. Patient did well in postoperative period and discharged after deworming with albendazole. There have been multiple reports of AL causing intestinal obstruction in endemic areas. Acutely sick patient presenting in emergency require resuscitation and may require emergency laparotomy followed by deworming with albendazole. In a patient presented with symptoms and signs suggestive of bowel obstruction, ascariasis should be considered as a differential diagnosis for those from endemic areas.
A review on Kaff Maryam (Anastatica hierochuntica L.): chemical constituents, pharmacological activities and role on fertility
(Medip Academy, 2024-10) Anzoom, S; Amran, MS.
Anastatica hierochuntica L., a plant widely used in folkloric medicine in Arab countries, has gained attention for its therapeutic properties. The plant is employed as an herbal remedy to address various diseases, including gynecological health issues. Its pharmacological effects are attributed to a diverse array of phytoconstituents, including steroids, triterpenoids, flavonoids, tannins, fatty acids, coumarins, alkaloids and more. According to research, A. hierochuntica has a variety of useful properties, including anti-cancer, antioxidant, anti-diabetic, anti-inflammatory, gastroprotective, immunostimulant, hepatoprotective and antibacterial properties. Notably, the plant has been recognized for its role in infertility treatment, with several scientific studies supporting its therapeutic value in this regard. This review aims to provide a comprehensive overview of A. hierochuntica, covering aspects such as plant description, traditional uses, chemical constituents and pharmacological activities. Emphasis is placed on the plant’s potential in infertility treatment and this review work explores possible mechanisms behind this role. The article underscores the multifaceted potential of A. hierochuntica in offering a variety of health benefits and encourages further exploration for its application in the development of novel treatments.
Role of doxycycline post exposure prophylaxis in the prevention of sexually transmitted infections: a narrative review
(Medip Academy, 2024-10) Waheed, F; Sher, A; Gul, M; Nisa, U; Saeed, A.
Sexually transmitted infections (STIs) spread through sexual intercourse. They are caused by pathogens like Neisseria gonorrhoeae, Treponema pallidum, Chlamydia trachomatis, and Mycoplasma genitalium, and can be transmitted through direct contact or contact with genital secretions. Doxycycline is a second-generation tetracycline antibiotic with a broad antimicrobial spectrum, acting on intracellular and extracellular organisms. This review aims to explore the efficacy of doxycycline post-exposure prophylaxis (PEP) in the prevention and treatment of STIs. Some of the areas of uncertainty with the use of doxycycline PEP for STIs include the concern for developing antimicrobial resistance (AMR), the effect on the normal microbiome of the body, public acceptability, drug formulation and dosage and compliance issues. Recent clinical and observational studies have looked at using doxycycline PEP to reduce the transmission of STIs. This review aims to explore these studies to provide a comprehensive account of the current state of doxycycline PEP and its future prospects. We also look at the limitations and areas of improvement in using doxycycline PEP, opening avenues for future research. High-quality studies have shown that using doxycycline PEP can effectively reduce the transmission of STIs in a number of clinical trials as well as systematic reviews., making it a potential standard treatment for high-risk groups such as immunocompromised patients, individuals living with HIV, sex workers, and men who have sex with men (MSM).
Evaluation of surgical dead space obliteration in modified radical mastectomy for incidence of seroma formation, drain volume and duration of drain
(Medip Academy, 2024-09) Jain, R; Yadav, DK; Kumar, V.
Background: Modified radical mastectomy (MRM) is commonly performed surgery in Breast Cancer. Seroma formation is commonly seen after MRM. This study was conducted to evaluate three potential dead spaces obliteration (DSO) technique i.e., interpectoral space, space between skin flaps and pectoralis major and axillary spaces for prevention of seroma and other post operative outcome comparison. Methods: A randomized prospective study of sample size 100 patients who were randomized into two groups. Group A undergoes MRM with DSO and group B undergoes only MRM. Post operative outcome were compared. Results: The mean drain output per day, seroma formation, and drain removal duration was statistically less in patients underwent DSO. Conclusions: Surgical dead space obliteration is a safe and feasible procedure which gives lower incidences of Seroma formation lesser postoperative complication and early removal of drain.
Determinants of puerperal sepsis among postpartum women admitted to hospitals in Dire Dawa, Ethiopia: an unmatched case-control study
(Medip Academy, 2024-09) Yasin, AM; Sintayehu, YS; Bedru, LA; Abdu, NR; Alemu, YB.
Background: Puerperal sepsis is an infection of the genital tract that occurs at any time from 2 to 42 days of puerperium. Despite various efforts undertaken, it remains among the leading causes of maternal mortality, including in Ethiopia. However, studies in Ethiopia have been inconsistent and lacking in the study area. Therefore, this study was aimed at assessing puerperal sepsis's determinants, which could help in interventions. Methods: A hospital-based unmatched-case control study was used among 600 postpartum women (150 cases and 450 controls). Cases (postpartum women with puerperal sepsis) and controls (postpartum women without puerperal sepsis) were selected by a systematic sampling technique. Data were collected using a structured questionnaire and a medical record review, entered and cleaned by Epi DATA (version 3.1), and analyzed using SPSS (version 22). A p value of 0.25 at bivariate to select variables for multivariate and ? 0.05 at multivariate with 95% confidence intervals was considered statistically significant. Results: Determinants of puerperal sepsis were housewives, merchants, rural residences, home deliveries, cesarean deliveries, and vaginal examinations and prolonged rupture of membranes. Conclusion: Puerperal sepsis determinants are primarily obstetric-related, with occupation and residence being the most significant. Accordingly, early interventions on all these determinant factors of puerperal sepsis could make a difference in overcoming morbidity and mortality related to puerperal sepsis. Thus, hospitals are recommended to conduct further research and improve institutional delivery and use standard procedures during the labor and delivery.
Exploring the perception of Afghan childbearing women about respectful maternity care: a qualitative study in Afghanistan
(Medip Academy, 2024-09) Hamdam, P.
Pregnancy and childbirth are critical periods for women, yet thousands of women and newborns die annually due to preventable factors. Despite global efforts, progress in reducing maternal mortality has been slow, especially in low-income and conflict-affected countries like Afghanistan. Respectful Maternity Care (RMC) is essential to improving maternal health outcomes, but mistreatment during childbirth in Afghan healthcare facilities deters women from seeking necessary care. This qualitative study explores the perceptions of Afghan childbearing women regarding RMC during childbirth. Through thematic analysis of interviews with nine women who recently gave birth in a major maternity hospital in Kabul, significant barriers and challenges were identified. The findings reveal that Afghan women frequently endure verbal and physical abuse, discrimination based on financial status and connections, lack of informed consent, and non-dignified care. These factors contribute to a lack of trust in facility-based childbirth, perpetuating high maternal mortality rates. The study underscores the urgent need to implement RMC practices that ensure fairness, compassion, and dignity to improve the maternal healthcare experience and outcomes in Afghanistan.
Anti-implantation and uterotonic properties of Mentha pulegium L. in female Sprague-Dawley rats
(Medip Academy, 2024-10) Sallah, L; Coffie, PN; Babatunde, DM; Danquah, CA; Baah, FK; Mante, PK; Owusu-Daaku, KO.
Background: Some traditional herbs disrupt endocrine-endometrial synchrony, affecting embryo-endometrium communication during fertility. Hormonal imbalances cause non-receptive conditions, leading to anti-implantation or abortion. Historically, Mentha pulegium has served for contraceptive and abortive purposes. Its effects on the post-coital contraceptive and hormonal activities were evaluated. Methods: Thirty-six Sprague-Dawley female rats were selected based on the presence of copulation plugs and received 200, 500, and 1000 mg/kg of Hydroethanolic leaf extract of Mentha pulegium L. (MPE) for seven days. Reproductive organ weights and serum estrogen and progesterone levels were measured. The resorption index, anti-implantation activity, and pre-implantation loss were also calculated using the number of implantation sites and resorptions in all treatments. Data were presented as mean±standard error mean (SEM), and significance was defined as p<0.05 using one-way ANOVA. Results: Post-coital administration of MPE resulted in resorptive, pre-implantation loss, and anti-implantation activity. A dose of 200 mg/kg reduced the number of implantations and exhibited a high resorption index, percentage pre-implantation loss, and anti-implantation activity. A marked decline in serum progesterone levels and a significant reduction in serum estrogen and progesterone ratio was observed at 200 mg/kg MPE. A significant increase in uterine weight was observed in the 500 mg/kg treatment. Doses of 500 and 1000 mg/kg resulted in a significant reduction in anti-implantation activity. Conclusions: The observed anti-implantation activity and pre-implantation loss suggest the abortifacient properties of MPE. However, its effects were seen to be dose-dependent.
Male systemic lupus erythematosus, rapidly progressive glomerulonephritis, and iatrogenic acute bone marrow failure: a case report
(Medip Academy, 2024-11) Das, UK; Chowdhury, EH.
Lupus nephritis (LN) is a significant complication of systemic lupus erythematosus (SLE), marked by kidney inflammation due to autoimmune activity, leading to proteinuria, hematuria, and potentially renal failure. Rapidly progressive glomerulonephritis (RPGN) is a rare, critical manifestation of LN characterized by a rapid decline in kidney function. This condition can lead to irreversible renal damage and is often fatal without prompt treatment. In this case, a 62-year-old man initially presented with fever, cough, and body aches, which were treated as an acute upper respiratory infection. Despite initial improvement, he developed persistent nausea, vomiting, and signs of renal dysfunction. Laboratory investigations revealed anemia, high erythrocyte sedimentation rate (ESR), electrolyte imbalances, and elevated creatinine. Imaging and endoscopy ruled out malignancy, and a differential diagnosis of multiple myeloma was excluded through plasma protein electrophoresis. Serological tests confirmed SLE, and subsequent renal biopsy revealed LN with RPGN features. Despite aggressive treatment with corticosteroids and cyclophosphamide, the patient’s condition rapidly deteriorated, leading to respiratory distress and intensive care unit (ICU) admission. He ultimately succumbed to his illness, underscoring the unpredictable and severe nature of RPGN in LN. This case highlights the importance of early diagnosis and intensive management to prevent rapid disease progression and improve patient outcomes.
Dienogest versus gonadotropin-releasing hormone analogues for the clinical treatment of endometriosis: an updated meta-analysis
(Medip Academy, 2024-12) Majeed, K; Hanif, ZM; Murtaza, M; Ali, H; Batool, A; Syed, H.
Endometriosis is a chronic gynecological condition where endometrial-like tissue grows outside the uterus, leading to persistent pelvic pain, dysmenorrhea, dyspareunia, and infertility. The objective of the systematic review was to examine the efficacy and safety of Dienogest, which is a synthetic, orally active 19-nortestosterone derivative, in the treatment of women with endometriosis compared to GnRH-a, which is commonly used to treat conditions like endometriosis. We conducted a search of PubMed, Google Scholar, and Cochrane Library databases from inception until August 2024 for clinical studies, using the following keywords: ("Dienogest") and ("gonadotropin-releasing hormone analogue" or GnRH Analogues OR GnRH agonist) and (Endometriosis). Relevant randomized control trials were identified. Pooled effect estimates were calculated using a random effect model. This meta-analysis included eight randomized controlled trials (RCTs) with 1,219 patients, 602 in the dienogest group and 617 in the GnRH analogue group. Both treatments were equally effective in controlling pain, dysmenorrhea, and dyspareunia, but dienogest offered advantages. Dienogest significantly reduced the recurrence rate (RR: 0.37, 95% CI [0.15, 0.91]; p=0.03) and hot flushes (RR: 0.24, 95% CI [0.10, 0.59]; p=0.002) and protected against bone mineral density (BMD) loss. However, it increased the risk of irregular vaginal bleeding (RR: 3.61, 95% CI [1.09, 11.97]; p=0.04). Other side effects, such as headache, vaginal dryness, spotting, and alopecia, were not statistically significant. It concluded that Dienogest has comparatively fewer side effects than GnRH analogue, making it a considerably safer option for treating endometriosis.
Angiotensin-converting enzyme insertion/deletion polymorphism as a potential risk factor of congenital heart disease: insights from a tertiary pediatric cardiac care centre from North India
(Medip Academy, 2024-12) Ahamad, S; Kukshal, P; Kumar, A; Chellappan, S; Sathe, Y; Murthy, PR.
Background: Our study aims to elucidate the genetic influence of angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism on congenital heart disease (CHD) in a north Indian cohort. Methods: 667 CHD cases, including 433 individuals with parental data and 104 controls were enrolled and genotyped by polymerase chain reaction. Case-control association, parental transmission test, and association of patients' and parents' clinical parameters with ACE I/D were explored. Results: Our findings highlight significant associations, notably the increased CHD risk conferred by the DD genotype in females (p=0.036; OR=1.68), its correlation with abnormal hemoglobin levels (p=0.049; OR=1.68), and its impact on primigravida (p=0.05). Conversely, the II genotype was found to significantly elevate the risk of CHD in offspring of tobacco-consuming fathers by 2.5-fold (p=0.029). Notably, cyanotic cases exhibited a heightened prevalence of ACE I/D mutations (p=0.059), with tetralogy of Fallot (TOF) showing the strongest association (p=0.024). Additionally, the DD genotype's involvement in conditions such as stenosis (p=0.026) and pulmonary artery hypertension (PAH) (p=0.05) underscores its clinical relevance. The parent of origin test showed maternal transmission of the D allele in combined (p=0.037) and acyanotic cases (p=0.039) and paternal transmission in ventricular septal defect (p=0.021). Conclusions: This is the first study from India and possibly the only study globally that reports a significant association between ACE I/D and CHD, highlighting the importance of genetic factors in CHD susceptibility.
Ramsay hunt syndrome: a case report
(Medip Academy, 2024-11) Amaravadi, D; Parvathalu, RK; Ravinder, SK.
Ramsay hunt syndrome (RHS) is a neurological condition comprising of complications with varicella zoster virus (VZV) which results in inflammation of geniculate ganglion. In the days to weeks following zoster, various cranial nerve palsies can develop because the varicella-zoster virus is latent in the cranial nerve ganglia. The trigeminal and facial nerves were the most commonly affected by zoster, based on the cranial nerve involvement. Another common impacted nerve was the vestibulocochlear nerve. As VZV is exclusively human pathogen, research on VZV latency is limited to only human ganglia examination. This case report describes about Ramsay Hunt Syndrome induced or also called as Herpes Zoster Oticus caused by Varicella zoster virus. Diagnosis mainly involved laboratory investigations, patient history, treatment data and other relevant information co-related from various literature. A 46-year-old female patient was diagnosed Ramsay hunt syndrome on the basis of clinical findings as right facial palsy, blisters over right pinna, otalgia and right ear erythematous lesions. Patient also exhibited deviation of angle of mouth to left side and unable to close right eye. This was accompanied by elevated erythrocyte sedimentation rate (ESR) exhibiting acute inflammation. Hemoglobin was low and total leukocyte count was high. Following that, corticosteroids and antivirals were prescribed to assist her medical condition. Remission is slow for RHS, hence patient was also advised for rehabilitation therapy to improvise her lower motor neuron facial palsy. Recurrence is possible in long term so it is imperative to initiate early treatment within 72 hours as soon as the symptoms are observed for better patient care.
Influence of preconception paternal age on the spontaneous abortion: a retrospective study
(Medip Academy, 2024-09) Sekhavat, L; Tabatabaie, RS.
Background: Due to the frequency of chromosomal abnormalities in sperm with increasing male age, the effect of increasing father's age as a cause of miscarriage is plausible, but there are still not enough studies available. The purpose of this study is to evaluate the effect of paternal age on spontaneous abortion. Method: In a retrospective study conducted on the files in the archives of Shahid Sadoughi Hospital in Yazd from 2020 to 2021, we reviewed the cases of 824 nulliparous pregnant women without systemic diseases or any risk for abortion. All women were under 35 years old with singleton pregnancies and aborted their babies before 20 weeks. Information collected included paternal age and paternal BMI. Results: A total of 104 cases were included in this study. In 10 cases, paternal ages were <20 in 15 cases, paternal ages were 20–30 in 35 cases, paternal ages were 31–40 and in 44 cases, paternal ages were >40 years. There was a significantly higher rate of abortion among paternal ages >40 years. Conclusions: Our study demonstrates that paternal age has an impact on abortion. The incidence of abortion increases among older fathers.
Operative treatment and postoperative complications of a frontal sinus fracture: a case report
(Medip Academy, 2024-12) Manukova, A; Bagante, I.
Frontal sinus fractures are significant injuries; they represent approximately 5-15% of all maxillofacial trauma cases. These fractures can cause complications and present important challenges. The type of surgical technique used, such as sinus reconstruction or obliteration, depends on the severity of the trauma and the general condition of the patient. The surgical treatment for frontal sinus fractures may include a coronal approach. The outcomes associated with frontal sinus fractures can range from mild headaches to severe complications, including cerebrospinal fluid (CSF) leakage; in cases of ineffective conservative treatment, surgical intervention may be necessary. TachoSil is used as a sealing agent during surgery to mitigate potential complications.
Massive retroperitoneal leiomyosarcoma: a case report
(Medip Academy, 2024-12) Kumar, V; Pathania, O; Siddiqui, AA; Kumar, D; Jain, R.
Soft tissue sarcoma is mesenchymal tumor of malignant in nature seen in body. Liposarcoma followed by leiomyosarcoma are most common type. Leiomyosarcoma (LMS) in retroperitoneum region develop from smooth muscle cell or from wall of large vein and detect clinically when attain huge size, causing symptom due to compression or displacement to surrounding structure. We are presenting case report of a 65 years old lady presented with progressive pain abdomen, distension, loss of weight and appetite for 1 year. Radiological investigation reveals a large bilobed intra-abdominal mass with no major vascular involvement. Patient underwent complete surgical excision with resection of surrounding structure and post operative period was uneventful. HPE and IHC of resected tumor were suggestive of Leiomyosarcoma. Leiomyosarcoma usually has slow and silent progression hence present clinically when compression or displacement of adjacent structure arises. It has malignant potential. Radiological investigation helps in deciding resection. R0 resection carries very good prognosis since chemo and radiotherapy has limited role in complete cure.
Cancer survivorship and long-term outcomes: navigating the challenges beyond treatment
(Medip Academy, 2024-11) Tali, TA; Amin, F.
The increasing number of cancer survivors due to advancements in early detection and treatment has shifted the focus of oncology to the long-term health and well-being of these individuals. Cancer survivorship encompasses a wide range of challenges that extend beyond the completion of treatment, including physical, psychological, social, and economic issues. This review explores the long-term physical health consequences of cancer treatment, such as neuropathy, cardiotoxicity, and chronic conditions, and highlights the psychological burdens, including anxiety, depression, and cognitive impairment, commonly faced by survivors. The article also addresses the social and economic impacts, such as difficulties in returning to work and financial toxicity, which further complicate the survivorship experience. Additionally, the review emphasizes the importance of assessing and improving the quality of life (QoL) for survivors through personalized interventions and the implementation of survivorship care plans (SCPs). Emerging research on biomarkers, telemedicine, and policy advocacy is discussed as critical components for advancing survivorship care. The review concludes that a comprehensive approach, including ongoing research, personalized care, and supportive policies, is essential to meet the diverse needs of cancer survivors and improve their long-term outcomes and QoL.
A case report of aggressive angiomyxoma of vulva: first appearance deceives many
(Medip Academy, 2024-12) Singh, A; Kumari, R; Deoghare, M; Agrawal, M; Mathur, S; Sharma, JB; Bhatla, N.
Aggressive angiomyxoma (AA) of the vulva is a rare, benign tumour of mesenchymal origin. It has marked tendency for local recurrence but rarely metastasize. We report a case of 35-years old, nulliparous women presented with bilateral, large vulval masses. Local examination revealed approximately 20×20 cm mass arising from right labia majora, nodular, firm, non-tender with overlying skin intact. Left vulval mass was approximately 15×10 cm arising from labia minora, nodular, firm, non-tender. Inguinal lymph nodes were not palpable. After thorough evaluation, she underwent excision of bilateral vulval masses with reconstruction. Histopathology revealed tumour composed of ovoid to spindle-shaped cells in a fibrous and myxomatous stroma with loosely interspersed collagen fibres suggestive of aggressive angiomyxoma. On immunohistochemistry, the tumour cells were focally positive for smooth muscle actin and desmin. Stains for acid-fast bacilli and fungus did not reveal any organisms. Her postoperative period was uneventful with good recovery. She is on follow up and no recurrence has been seen so far in follow-up period of 15 months. AA should be kept in mind as one of the differential diagnoses in evaluation of large vulval masses. Keeping this rare entity in mind and relevant investigations may help in reducing the misdiagnosis and avoiding any mutilating surgery. Multidisciplinary approach can be crucial in management of such cases.
Impact of discounts on sales in Delhi NCR: a survey report
(Medip Academy, 2024-11) Meena, R; Kumar, A.
Background: Delhi NCR, which includes Delhi and its neighbouring areas, has experienced considerable growth in the shopping sector over the past decade. A major factor that draws customers to these shopping destinations is the opportunity for bargaining and discounts. This paper examines the impact of discounts on the sales of various item categories. Methods: A survey has been conducted to collect data. Along with focus on responses to a structured questionnaire, the study also analyses sales across various groups of items, with each group divided into two categories: one offering discounts and the other not. Results: findings of this study have the potential to shed light on the fact that offering discounts is beneficial and finally leads to increase in sales as it attracts more customers. For most the groups an increase in sales has been witnessed. Conclusions: From the findings of the study, it can be concluded that if discounts are offered, more customers are attracted which eventually leads to increase in sales day by day.
General and microbiological chronic diseases into humans
(Medip Academy, 2024-10) Chandra, M; Paray, AA.
Chronic illnesses including cancer and cardiovascular disease (CVD) are among the world's major causes of death and have become more prevalent in the last ten years. Microbial agents and the emergence of chronic diseases (CDs) have been linked in the past, and new links are presently being investigated. Researchers are employing new technology to investigate the connection more thoroughly and precisely between infectious pathogens and chronic illness.
Factors predisposing to neonatal sepsis in Yenagoa Nigeria
(Medip Academy, 2024-09) Ogbara, CN; Nwose, EU.
Background: Neonatal unit of the hospital is the hallmark of intensive care hence the full name of the department is neonatal intensive care unit (NICU), and sepsis is prevalent. Predisposing factors to the occurrence of neonatal sepsis is something to be regularly reviewed. This commentary seeks to advance findings from a dissertation on predisposing factors of sepsis NICU. Methods: This was based on critical review of a mixed method study involving clinical observation and survey approaches using purposive sampling techniques. 66 questionnaires were administered to the health professionals working in the NICU of the two tertiary hospitals. Statistical analysis was in frequency description research method. Results: 83.3% of the participants were females and 97% are above the age of 18 years old. Using 2.5/5 as benchmark of the Likert scale, results revealed socio-economic, maternal healthcare, neonatal health, and hygienic delivery practice as main predisposing factors with averages over 3.23. The level of healthcare professionals’ adherence to general infection control measures was found to be moderate (2.6±0.4 out of 5.00). The result also revealed that mothers and visitors adhered abysmally to the use of personal protective equipment (1.7±0.4 out of 5.0). Conclusion: The hygiene level of the health workers and mother/visitors to the NICU may likely be a predisposing factor to the occurrence of neonatal sepsis. Infection control compliance monitoring to avoid sepsis among neonates is strongly recommended.

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