MicroRNAs as regulators of cutaneous wound healing.
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Date
2014-06
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Abstract
MicroRNAs (miRNAs) have emerged as key post-transcriptional regulators of gene expression, and have displayed
important roles in areas spanning from embryonic development to skin physiology. Despite this, till now little is
known about the significance of miRNAs in cutaneous wound healing. In this mini-review, we discuss the existing
evidence on the roles of miRNAs in physiological processes relevant to cutaneous wound healing, followed by a
highlight of the prospects and challenges of future development of miRNA-based wound therapies. With existing
technologies of nucleic acid transfer and miRNA modulation, it is anticipated that once the roles of miRNAs in wound
healing have been clarified, there will be a vast new vista of opportunities brought up for development of miRNAtargeted
therapies for wound care.
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Keywords
Angiogenesis, inflammation, microRNA, e-epithelialization, wound healing
Citation
Lai Wing-Fu, Siu Parco M. MicroRNAs as regulators of cutaneous wound healing. Journal of Biosciences. 2014 Jun; 39 (3): 519-524.