Insights into eisosome assembly and organization.
Loading...
Date
2012-06
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Eisosomes, large protein complexes that are predominantly composed of BAR-domain-containing proteins Pil1 and
its homologs, are situated under the plasma membrane of ascomycetes. A successful targeting of Pil1 onto the future
site of eisosome accompanies maturation of eisosome. During or after recruitment, Pil1 undergoes self-assembly into
filaments that can serve as scaffolds to induce membrane furrows or invaginations. Although a consequence of the
invagination is likely to redistribute particular proteins and lipids to a different location, the precise physiological role
of membrane invagination and eisosome assembly awaits further investigation. The present review summarizes recent
research findings within the field regarding the detailed structural and functional significance of Pil1 on eisosome
organization.
Description
Keywords
Eisosome, membrane organization, Pil1
Citation
Murphy E R, K T Kim. Insights into eisosome assembly and organization. Journal of Biosciences. 2012 Jun; 37 (2): 295-300.