Primary Osteosarcoma of the Breast.
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Date
2012-06
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Abstract
Primary osteosarcoma of the breast is an extremely rare
and aggressive tumor representing 12.5% of mammary
sarcomas. It is associated with early recurrence and
hematogenous rather than lymphatic spread, most
commonly to the lungs. We report a case of 55 year old
lady with gradually increasing painless lump measuring 7 ×
6 cm in upper outer quadrant of left breast of 2 months
duration. FNAC smears revealed pleomorphic spindle cells
admixed with osteoid and chondroid material. A differential
diagnosis of metaplastic carcinoma and malignant phyllodes
tumor was offered. Histopathology of the modified radical
mastectomy specimen showed predominantly
osteosarcomatous areas. Epithelial component was not seen
even after extensive sampling of the tumor. On
immunohistochemistry, vimentin, S100 and CD68 were
positive while AE1/AE3, CAM5.2, ER, PR, Her2-neu and
desmin were negative confirming a diagnosis of
osteosarcoma. Primary osteosarcoma of breast must be
differentiated from metaplastic carcinoma and malignant
phyllodes tumor because of different biological behaviour
and treatment approach. Immunohistochemistry plays a
pivotal role in the diagnosis of this tumor.
Description
Keywords
primary osteosarcoma, breast, mammary sarcoma
Citation
Badge S A, Lanjewar D N, Gosavi A V, Ramteerthkar N A, Kulkarni M P. Primary Osteosarcoma of the Breast. Indian Medical Gazette. 2012 Jun ; 145 (6): 249-252.