Co-circulation of dengue virus serotypes with chikungunya virus in Madhya Pradesh, central India.
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Date
2014-01
Journal Title
Journal ISSN
Volume Title
Publisher
WHO Regional Office for South-East Asia
Abstract
Background: Dengue and chikungunya present with very similar signs and
symptoms in the initial stage of illness and so it is difficult to distinguish them
clinically. Both are transmitted by Aedes aegypti and Aedes albopictus mosquitoes.
This study was conducted with the aim to explore the co-circulation of dengue and
chikungunya viruses in central India.
Materials and methods: Samples from suspected dengue cases were subjected
to dengue immunoglobulin M (IgM) enzyme-linked immunosorbent assay (ELISA)
and dengue-negative samples were tested with chikungunya-specific IgM ELISA.
The samples collected in acute phase of illness were tested by nested reverse
transcription polymerase chain reaction (nRT-PCR). Chikungunya virus (CHIKV)
sequences were analysed to determine their genotype.
Results: Of 138 samples screened for dengue, 21 (15.2%) were positive, and of
119 samples screened for chikungunya, 13 (10.9%) were positive. Dengue viruses
1 and 4 were found co-circulating with chikungunya virus in Jabalpur, central
India. The chikungunya virus detected belonged to the East Central South African
genotype.
Conclusion: Accurate and timely diagnosis would help in patient management
and use of resources. It is advocated to simultaneously test samples for these two
diseases in endemic areas. This will also aid in understanding the epidemiology
of chikungunya.
Description
Keywords
Central India, chikungunya, co-circulation, dengue
Citation
WHO South-East Asia Journal of Public Health 2014;3(1): 36-40.