The Efficacy and Undesired Effects of High Dosage Zinc Treatment.
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Date
2011-03
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Abstract
Zinc is an essential micronutrient for human health. It is very important for body
functions, and they have an interaction potential in several systems, including nervous system.
Although there is no global regulation about the daily amounts, it is shown to reduce the
incidence of diarrhea and pneumonia. Zinc deficiency is a global problem, especially in
developing countries. Zinc has been shown to be effective in treatment of zinc deficiency,
Acrodermatitis Enteropathica, protein energy malnutrition (PEM), Wilson disease, pica,
diarrhea, unrecovering ulcers etc. Although under 50 mg daily is enough for diarrhea, anemia,
infections, immundeficieny etc., higher dosages may be required in Wilson`s disease, pica and
acrodermatitis enteropathica up to 220 mg daily. Also it was reported that high dosage of zinc
treatment can lead neurotoxity, Alzheimer`s disease or impaired lipid metabolism. So caution
should be exercised when prescribing the zinc to the patients who have risk for neurotoxity,
Alzheimer`s disease or impaired lipid metabolism.
Description
Keywords
Zinc Treatment, micronutrient, Zinc deficiency
Citation
Kockaya Guvenc, Ufuktepe Baran, Kockaya Pinar Daylan, Sen Selcuk, Altunel Ozlem, Uresin Yagiz. The Efficacy and Undesired Effects of High Dosage Zinc Treatment. Journal of Applied Pharmaceutical Science. 2012 Mar; 2(3): 157-159.