Structure activity relationship studies of synthesised pyrazolone derivatives of imidazole, benzimidazole and benztriazole moiety for anti-inflammatory activity.
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Date
2011-06
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Abstract
In the present investigation, a series of some synthesis and biological evaluation of some
pyrazolone derivatives with imidazole, benzimidazole and benztriazole moiety were synthesized and
tested for their anti-inflammatory activity in-vitro using celecoxib as a reference drug. Compound 8d
was found to be the most potent derivative of the series with 75 %inhibition of inflammation.
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Keywords
Pyrazolone, imidazole, benzimidazole, benztriazole, %inhibition of inflammation
Citation
Soni Julee P, Sen Dhrubo Jyoti, Modh Kamal M. Structure activity relationship studies of synthesised pyrazolone derivatives of imidazole, benzimidazole and benztriazole moiety for anti-inflammatory activity. Journal of Applied Pharmaceutical Science. 2011 Jun; 1(4): 115-120.