Review : Cardio vascular complication of diabetes mellitus.
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Date
2011-06
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Abstract
Now day diabetes is very common world wild disease. Basically two type of diabetes:
Type-I and Type-II. Various short term complications like diabetec ketoacidosis, hyperosmolar
nonketotic coma and hypoglycemia and long term complication like diabetec neuropathy,
diabetec retinopathy, diabetec nepheropathy, diabetec microangiopathy, heart disease and stroke
occur due to diabetes mellitus. Cardiovascular complication mainly occurs by either increase of
glucose by activation of protein kinase, rennin angeotensin system, advance glycation endproduct
theory i.e. AGE-RAGE or by metabolic syndrome and insulin resistance mechanism
which precipitates obesity, physical inactivity and genetic susceptibility. Insulin secretion is
decreases with advancing age which may be accelerate by genetic factor. Insulin resistance led
to onset of Type-II diabetes mellitus and is commonly associated with other cardio vascular risk
factors like dysbetalipidema, hypertension and prothombic factor. Evaluation of these major risk
factors is very necessary. Predisposing risk factors are body weight and fat distribution in the
body, physical activity and family history. Detection of clinical and sub clinical cardiovascular
disease in diabetic patient. Evaluation of factor such as a stress testing for coronary heart
disease, non-invasive evaluation of cardiac function, evaluation of autonomic dysfunction,
detection of sub clinical cardio vascular disease and it treated by changing life style or by using
insulin matrix.
Description
Keywords
Complications, Mechanism, Various systems play role in this mechanism, Management, insulate matrix
Citation
Patel Chintan A, Pathak Nimish L, Bhatt Nayana, Marya Bhavna, Gavania Mahendra, Trivedi Hardik. Review : Cardio vascular complication of diabetes mellitus. Journal of Applied Pharmaceutical Science. 2011 Jun; 1(4): 1-6.