International Journal of Reproduction, Contraception, Obstetrics and Gynecology
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Editor in Chief: Dr. Bhaven Kataria
Print ISSN: 2320-1770 (Print)
Frequency: 4 issues a year
Language: English
Open Access Peer-reviewed journal
Web site: https://www.ijrcog.org/index.php/
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Item Caesarean section under spinal and epidural anesthesia in complete atrioventricular block without a pacemaker: a rare case report(Medip Academy, 2023-11) Mishra, Vineet V.; Rane, Priyanka H.; Choudhary, Sumesh; Shah, Kunur N.Complete heart block (CHB) during pregnancy is rarely encountered. Management requires a multidisciplinary approach involving the obstetrician, cardiologist, anesthetist, and neonatologist. Treatment varies from medical management to temporary or permanent pacemaker insertion. Complete atrioventricular block comprises complete absence of AV conduction - none of the supraventricular impulses are conducted to the ventricles. Perfusing rhythm is maintained by a junctional or ventricular escape rhythm. Typically, the patient will have severe bradycardia with independent atrial and ventricular rates. The incidence is 1 in 15,000 to 20,000 live births. We successfully managed caesarean section in a pregnancy with complete atrioventricular block under spinal and epidural anesthesia without a pacemaker. Asymptomatic pregnant women with congenital complete atrioventricular block can tolerate caesarean section under spinal and epidural anesthesia without a pacemaker.Item Symplastic leiomyoma: a rare clinicopatholgical diagnosis(Medip Academy, 2023-11) Shenoy, Kavitha V.; N., Usha; Priyadarshini, Sarah GraceAlthough leiomyomas are common爐his case is being reported due to its uniqueness as it posed challenges at all levels of pathological rarity and management. Symplastic leiomyoma is an unusual benign variant of leiomyoma with less likelihood of malignant transformation. In our case report we present a 28-year-old nulligravida who presented to our OPD with Fibroid uterus detected on scan and myomectomy specimen done revealed燼 rare pathological diagnosis of symplastic leiomyoma and her followup.Item Sarcoidosis presenting as ovarian mass with omental and peritoneal nodules with elevated CA 125 level; mimicking malignancy(Medip Academy, 2023-11) Badanale, RenukaSarcoidosis is a systemic inflammatory disease of unknown aetiology with a variety of nonspecific clinicoradiological features making diagnosis challenging. Sarcoidosis commonly involves pulmonary and lymphoreticular systems; ovarian involvement being extremely rare. We present a case of a 50-year Indian postmenopausal female, with a history of abdominal pain and distension, referred from the peripheral hospital for management of a solid complex left adnexal mass and elevated CA 125 levels. Based on ultrasonography and contrast-enhanced computed tomography, ovarian carcinoma was a differential diagnosis. Ascitic and pleural fluid cytology and ovarian fine needle aspiration cytology (FNAC) didn抰 give any conclusive diagnosis. Hence surgical intervention was carried out. Histopathology revealed noncaseating granulomas in ovaries, peritoneum, and omentum. Tissue polymerase chain reaction (PCR) for tuberculous and nontuberculous mycobacteria was negative. Post-operatively serum angiotensin-converting enzyme (ACE) and calcium levels were elevated. These findings supported the diagnosis of sarcoidosis and the patient responded well to systemic steroids.Item ANC with acute abdomen: a case report from secondary care hospital, Western Maharashtra(Medip Academy, 2023-11) Rathore, Nalini; Tripathi, V. B.; Dixit, NilamFemale body undergoes numerous anatomical and physiological changes in pregnancy which make diagnosis and management of acute abdomen in pregnancy as a most challenging situation. This may lead to dilemma and delayed identification of spectrum of causes of acute abdomen in pregnancy ultimately resulting in maternal and foetal morbidity and mortality. This case was to identify the spectrum of causes, the clinical presentation and diagnostic dilemma of acute abdomen in pregnancy. We presented one of the unusual and rare cause of acute abdomen with hemoperitoneum. Patient underwent emergency laparotomy with peritoneal wash with no obvious bleeding cause but evidence pointing towards vascular tumour or sub-serosal fibroid. The diagnosis remained obscured. The dilemma was attributed to higher radiological imaging with possibility of Haemorrhagic corpus luteum and non-viable heterotopic pregnancy. The cause of bleeding could not be identified with higher imaging due to contraindicated use of contrast enhanced MRI/CT and other alternatives due to radiation exposure in pregnancy. Diagnosis and treatment of acute abdomen in pregnancy should be individualized for better prognosis. Good clinical acumen is essential for ordering early diagnosis and intervention in acute abdomen in pregnancy.Item A successful pregnancy outcome after mitral valve replacement: a case report(Medip Academy, 2023-11) Mishra, Vineet V.; Rane, Priyanka H.; Aggarwal, Rohina S.; Shah, Kunur N.Valvular heart disease can be acquired or congenital. Although the incidence of rheumatic heart disease is on the decline, the number of patients with congenital heart disease who survive into adulthood has grown substantially over the past 30 years. Therefore, a large number of patients with valvular heart disease will be of childbearing age. Here we presented a case of second gravida who was diagnosed with rheumatic heart disease and had undergone mitral valve prosthesis and tricuspid valve repair delivered a healthy live male baby weighing 2.250 kg.Item A case report of intrahepatic cholestasis of pregnancy with acute pancreatitis(Medip Academy, 2023-11) Lewis, Preeti Frank; Vinkare, Pratima V.Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells. As a result, bile builds up in the in the liver, impairing liver function. The problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis. Intrahepatic cholestatsis of pregnancy usually becomes apparent in the third trimester of pregnancy. Bile flow returns to normal after delivery of the baby, and the signs and symptoms of the condition disappear. However, they can return during later pregnancies. Intrahepatic cholestasis of pregnancy can cause problems for the unborn baby. The condition is associated with an increased risk of premature delivery and stillbirth. Additionally, some infants born to mothers with intrahepatic cholestasis of pregnancy have a slow heart rate and a lack of oxygen during delivery (fetal distress). Acute pancreatitis is defined as the sudden inflammation of pancreas manifested clinically by abdominal pain, nausea of dehydration that is usually self-limiting but occasionally can progress to severe disease and even death. Most cases of acute pancreatitis in pregnancy are caused by gallstone disease. It is thought with the weight and hormonal changes induced by pregnancy, gallstones are more likely to form and thus travel down the common bile duct to obstruct the pancreatic duct outflow. Another proposed mechanism for acute pancreatitis in pregnancy is high fat levels in the blood called triglycerides. Again, the hormonal changes of pregnancy can predispose certain women to developing this condition. When the triglycerides levels become too high, oxygen cannot adequately travel to the pancreas via bloodstream, and pancreatitis can ensue. Acute fatty liver of pregnancy (AFLP) is a rare but life-threatening complication that typically occurs in the third trimester of pregnancy. Extant studies show the low incidence of AFLP ranging from 1/7000 to 1/20000. Maternal mortality is 10% to 15%, and fetal mortality is up to 20% . The severity of this disease underscores the need for early diagnosis and management. The clinical diagnosis of AFLP is challenging, and the differential diagnoses includes other peripartum conditions such as severe viral hepatitis, pre-eclampsia, hemolysis, elevated liver enzymes, and a low platelet count (HELLP) syndrome or thrombotic microangiopathies. The primary treatment for AFLP includes rapid pregnancy termination and symptomatic therapy. Liver transplantation has been considered a last resort. We reported the case of 20-year-old primigravida at 36 weeks of gestation who developed IHCP mimicking Acute fatty liver of pregnancy with Acute Pancreatitis, however with multidisciplinary team approach she had a good feto-maternal outcome.Item Mature cystic teratoma mimicking ectopic pregnancy: a case report(Medip Academy, 2023-11) Verma, Deepak; Kumar, Sumit; Sachdev, NamritaWe present a case of mature cystic teratoma resembling ectopic pregnancy in a patient with positive serum beta-hCG and an adnexal mass. A 30-year-old woman who was experiencing pelvic pain and vaginal bleeding was sent to the emergency room. An ultrasound revealed a complex right adnexal mass measuring 63� mm and the absence of an intrauterine gestational sac. Based on these findings, ectopic pregnancy was suspected; nevertheless, a subsequent magnetic resonance imaging (MRI) was planned, which suggested mature cystic teratoma. On a laparoscopy, later findings were verified. Cyst removal was the patient's treatment. Despite the possibility of an ectopic pregnancy being indicated by the existence of an adnexal mass without an intrauterine gestational sac and a positive beta-hCG level, a mature cystic teratoma should be considered as a differential diagnosis.Item Asymptomatic secondary abdominal pregnancy diagnosed 12 years after tubectomy(Medip Academy, 2023-11) Bulusu, Ratna; Biradar, Kalavathi D.; V., VijayalakshmiAbdominal pregnancy is a rare obstetric complication with high maternal mortality. Advanced abdominal pregnancy is rare and accounts for 1 in 25,000 pregnancies. 32 years� lady, P2L2, last child birth and interval tubectomy by modified Pomeroy抯 method 12 years ago, reported with Amenorrhoea of two months with vague lower abdominal pain since 2 days. Ultrasonography (USG) abdomen and pelvis showed an extrauterine viable pregnancy of 20+ weeks POG with no hemoperitoneum. she travelled 4 hours by road to her hometown, for second opinion and was referred back to our institution. A laparotomy was done; hemoperitoneum of 1.5 litres was noted. The sac with the live foetus inside with placental implantation seen on entire left fallopian tube except the fimbrial end and a small portion of omentum was noted. Left salpingectomy with excision of the sac with the foetus along with partial omentectomy was performed. Patient received two units of PRBC postoperatively.Item Fetal umbilical vein aneurysm(Medip Academy, 2023-11) Samuel, Raisa; Navaneethan, PreethiFetal umbilical vein aneurysm is an uncommon anomaly also known as umbilical vein varix. It accounts for 4% of umbilical cord abnormalities with an incidence of 0.4-1.1/1000. The etiology of fetal vein aneurysm has not been well established. The diagnosis is made by colour doppler sonography. The management of umbilical vein aneurysm is yet in process of establishment. The possibility of sudden hemodynamic change caused by aneurysm or thrombosis needs to be screened on a regular basis and early delivery can be considered in need.Item Heterotopic pregnancy in a rural area in Haiti: case report(Medip Academy, 2023-11) Jean, Marie B閠y; Dorc閘us, Ludentz; Bouloute, MakenzyHeterotopic pregnancy can be defined as the coexistence of at least two pregnancies in different implantation sites. It抯 a rare entity, but its diagnosis is becoming more common because of assisted reproduction techniques and ultrasound improvement techniques. The clinical symptoms are also similar to ectopic pregnancy, but a high suspicion index is needed to avoid diagnosis delay and subsequent unfavourable outcomes. This is the case of a 36-year-old female with heterotopic pregnancy who presented with shock symptoms and substantial delay in diagnosis due to socio-political crisis in Haiti at the time. Initial hemoglobin was at 6 g/dl. Transabdominal ultrasound showed an intra-uterine live fetus of 11 weeks 6 days along with a left adnexal mass and free fluid in the Douglas cul-de-sac. She was urgently transferred to the operation room where we performed a left annexectomy through laparotomy. She didn抰 get blood transfusion due to shortage at the blood bank of the hospital. The patient抯 post-op and pregnancy course were uneventful until the vaginal birth of her child who is alive and well today. We want to highlight the importance of optimizing healthcare access to the most vulnerable and careful adnexal evaluation. It is also important to reinforce the health system in Haiti to secure prenatal care and blood transfusion for all pregnant women.Item Endometrial thickness in perimenopausal women with abnormal uterine bleeding(Medip Academy, 2023-11) Bharatnur, Sunanda; Shetty, TrishaBackground: Abnormal uterine bleeding (AUB) is the most common presenting menstrual complaint in women of perimenopausal age group. During this period, the endocrinological, biological and clinical features of approaching menopause commence. The incidence of uterine pathology increases in this age group. The objective of current study is to measure the endometrial thickness by transvaginal scan in perimenopausal patients with AUB and comparison of histopathological outcomes.Methods: This is a prospective observational study in the department of obstetrics and gynecology at Srinivas institute of medical sciences and research Centre from August 2022 to August 2023. This study included total of 115 patients with AUB between 40 to 52 years of age.Results: Among 115 patients in the study most of the patients were between 44-47 years of age. Majority of the women were multiparous (97.4 %). Transvaginal ultrasound examination revealed 105 out of 115 patients had endometrial thickness between 12-22.9mm. On HPE 92 out of 115 patients to have simple hyperplasia without atypia. Correlation between TVS and endometrial thickness shows that only 0.86% of patients with endometrial thickness between 12-22.9 has complex hyperplasia with atypia.Conclusions: Transvaginal scan is a simple, convenient and economical way to indirectly visualize the endometrial cavity. It can be used to accurately distinguish between normal and pathological endometrial conditions in patients with AUB in perimenopausal age group.Item Evaluation of psychological stress in pregnant females during COVID era(Medip Academy, 2023-11) Kaur, Prabhneet; Sehgal, Alka; Tandon, Rimpy; Deepti; Arun, PritiBackground: Anxiety and depression may affect 20-40% of pregnant women with concerns about foetal well-being, maternal health, social and financial support, and even death. During the COVID Era, fear of contracting illness, restricted availability of healthcare services, and stresses secondary to job loss were expected which led to an increase in pre-existing psychopathology as well as new onset of psychiatric disturbances. Hence it was decided to carry on a screening study to evaluate psychological stress among pregnant women during the COVID-19 pandemics related to it.Methods: A questionnaire-based prospective study was conducted amongst pregnant women visiting Government Medical College and Hospital, Chandigarh in three months (June 2020 to August 2020) during the COVID Era. Among 162 subjects, 30 pregnant healthcare workers and 32 COVID-positive pregnant women were included. All COVID-appropriate behaviour and precautions were followed while filling out the questionnaires.Results: Fear symptoms were present in 52.5% of pregnant women. All the fears were significantly more amongst the healthcare workers which could be due to more knowledge or since they were direct observers of COVID load. Fear of breastfeeding was more common among COVID-19 positives and was significant.Conclusions: Screening and education should be made necessary components of prenatal care with the implementation of a multidisciplinary approach to tackle this aspect of maternal mental health.Item Study to detect infection and diagnose chorioamnionitis to aid in management of cases of preterm premature rupture of membranes in a tertiary care centre of Jharkhand(Medip Academy, 2023-10) Dutta, Indrani; Horo, Usha MadhulikaBackground: The present study undertaken is to identify the risk factors causing Preterm premature rupture of membranes (pPROM) and to study fetal and maternal outcome associated with pPROM, to diagnose and manage chorioamnionitis associated with pPROM and to evaluate levels of C reactive protein (CRP).Methods: This study was conducted in the department of obstetrics and gynaecology, Rajendra institute of medical sciences from March 2019 to February 2020.50 cases of confirmed preterm premature rupture of membrane before 35 weeks of pregnancy were taken as cases and 50 cases of normal pregnancy (28-40 weeks) were taken as controls.Results: Highest incidence of premature rupture of membrane was among 20�-year (68%) age groups. Incidence of premature rupture of membrane was more in low socioeconomic status (72%). Maximum incidence of premature rupture of membrane in 31-33 weeks gestational age (52%). Most cases of premature rupture of membrane in 24�-hour group (38%). Most of study group (90%) and control group (80%) delivered by vaginal route. 11 study cases with clinical chorioamnionitis had elevated CRP (43.5 mg/l). One presented with clinical chorioamnionitis. CRP was most sensitive (92%). Total maternal morbidity was due to puerperal pyrexia (22%). Four patients with neonatal sepsis had CRP>6 mg/l. CRP and presence of polymorphs in gastric aspirate have 100% association with septicemia in neonates.Conclusions: Preterm premature rupture of membrane can be associated with adverse foetal and maternal outcome if immediate measures are not taken.Item A study of risk factors and fetomaternal outcome in patients with antepartum haemorrhage in a tertiary care centre(Medip Academy, 2023-11) Chauhan, Jigisha; Gheewala, Amisha; Patel, Vishwa; Patel, Henna; Agrawal, ShreyaBackground: Antepartum haemorrhage (APH) is one of the most feared complications in obstetrics, contributing to a significant amount of maternal and perinatal morbidity and mortality in our country. An antepartum haemorrhage is defined as bleeding into or from the genital tract from 24 weeks� gestation and onwards, before the delivery of the baby. APH complicates about 2-5% of all the pregnancies with incidence of placenta previa (PP) about 0.33% to 0.55% and incidence of abruptio placenta (AP) about 0.5-1%. The maternal complications seen in patients with APH are malpresentations, premature labour, postpartum haemorrhage (PPH), sepsis, shock and retained placenta and the various foetal complications are preterm baby, low birth weight, intrauterine death, congenital malformation and birth asphyxia.Methods: A 45 patients were included in this descriptive study and detailed history taking and clinical examination was done and the resultant maternal and neonatal outcome was noted.Results: Incidence of APH in current study was calculated to be 0.53%. Out of the 45 patients, 28 (62.3%) were diagnosed with placenta previa and 17 (37.8%) were diagnosed with abruptio placenta. All 45 patients underwent caesarean section. 3 patients (6.6%) underwent obstetric hysterectomy due to diagnosis of placenta accreta spectrum. 35 alive and 8 dead born foetuses were delivered. 40% of new borns were admitted in NICU.Conclusions: Antepartum haemorrhage is a major cause of maternal and perinatal morbidity and mortality which can be prevented by early antenatal registration, regular and frequent antenatal visits, early detection and labelling of high-risk cases, and early referral to higher centre when indicated.Item Role of ferric carboxymaltose in battle with anemia among north Indian pregnant women(Medip Academy, 2023-11) Verma, Urvashi; Bharati, Sadhana; Jain, Meena; Asha; Singh, Saroj; Garg, RuchikaBackground: Anemia among pregnant women is a serious global health concern. Anemia is a major hematological, nutritional deficiency but still a manageable health problem among the pregnant women and very common in developing countries like India in under privileged population. Increased morbidity and mortality is seen in pregnant women and their foetuses suffering from anemia. Aim of this study was to study safety and efficacy of injection ferric carboxymaltose in pregnant women with iron deficiency anemia.Methods: This is a Prospective interventional comparative randomized study carried among antenatal women in the Department of Obstetrics and Gynaecology, S. N. Medical College, Agra from (May 2021-October 2022), comprised of 200 pregnant women divided into two groups. Group A-100 antenatal women were transfused with iron sucrose (IS), Group B-100 antenatal women were transfused with ferric carboxymaltose (FCM).Results: In FCM group after 3 weeks of post transfusion hemoglobin level was 10.5�44 and in iron sucrose group it was 9.9�59 (p=0.0001). 6 week post transfusion hemoglobin level in FCM group was 11.37�62 and in iron sucrose group it was 10.45�59 (p=0.0001). Average rise in hemoglobin in FCM group after 3 week post transfusion was 2.9�02 and after 6 week it was 3.77�16. In iron sucrose group at 3 week it was 2.1�06 and at 6 week it was 2.65�04. The average rise in hemoglobin level was greater among patients of FCM compared to Iron sucrose group.Conclusions: Ferric carboxymaltose was safe and more effective in treatment of iron deficiency anaemia in pregnant women as compared to iron sucrose with lesser side effect and better patient compliance.Item Serum magnesium level at 24 to less than 37 weeks: a prospective COHORT study predicting spontaneous preterm delivery(Medip Academy, 2023-11) Astha; DivyaBackground: Preterm labour is a leading cause of perinatal morbidity and mortality. Out of various causes, many macronutrients and micronutrients are said to have a role in pathogenesis of preterm labour, one of them is magnesium. Magnesium inhibits myometrial contractions by antagonizing calcium mediated uterine contractions. With advancement of pregnancy serum magnesium levels falls causing hyper excitability of neuromuscular junction bringing in uterine hyperactivity. The study was aimed to measure and compare the level of serum magnesium in preterm labour and normal pregnancy and to find the association of serum magnesium level with preterm labour.Methods: This cohort observational study was done in Department of Obstetrics and Gynaecology, King George's Medical University, Lucknow and eligible participants i.e., pregnant women with singleton gestation between 24 and <37 weeks of gestation were enrolled.112 women with preterm labour and 120 with no preterm labour were taken as study and control group respectively, serum magnesium level measured and followed till delivery.Results: The study showed mean serum magnesium level was 1.79�22 mg/dl in study group as compare to 1.98�25 mg/dl in control group and the difference was statistically significant (p<0.001). The value of Serum Magnesium below 1.885 mg/dl had a sensitivity of 64.8% and specificity of 66.1%.Conclusions: We can conclude that low serum magnesium is associated with preterm labour and serum magnesium estimation in pregnancy may be a valuable marker of predicting preterm labour.Item Prediction of preterm premature membrane rupture by the platelet-lymphocyte ratio(Medip Academy, 2023-11) Sultana, Nargis; Karim, Farha; Rahman, Mohammad KhalilurBackground: Premature rupture of membranes is a significant obstetric problem. Evaluating platelet -lymphocyte ratio is expected to illuminate the potential scope of early prediction of PPROM. This study showed that PLR could be a new inflammatory marker for diagnosing preterm PROM.Methods: The study place was the燚epartment of Obstetrics and Gynaecology, Sir Salimullah Medical College & Mitford Hospital, Dhaka, Bangladesh, from May 2019 to October 2019.燫esults: It was a case-control study. All mothers were selected by purposive sampling who were PPROM as cases. Age-matched non-PPROM pregnant women at term were also enrolled as control. Afterward, they were scrutinized according to eligibility criteria, and 200 mothers were enrolled. Among them, 100 were cases, and the other 100 were in control. A pre-tested, observation-based, peer-reviewed data collection sheet was prepared before the study. Data regarding clinical, biochemical, and surgical profiles were recorded. Data were compiled, edited, and analyzed. The P-value was determined by the chi-square test (categorical variables) and the student抯 t-test (continuous variables). The p-value was significant at <0.05.Conclusions: The mean age of 100 patients from the case was 24.39�81 (age range: 18-36) years, and that of the control, like 100 normal pregnant women, was 24.31�34 (age range: 19-35) (p=0.49). The mean parity of case and control were 2.1�9 (range: 0-5) and 1.98�2 (range: 0-3). The mean gravida of case and control were (3.1�2 vs. 3.4�4). Platelet count was found to be significantly higher in preterm PROM group (case) than control (241.6�.7�00/mm� vs. 201.7�.9 �00/mm�), p value is <0.001 which is statistically significant. So, PLR might be an excellent inflammatory biomarker to predict preterm PROM.Item Role of mifepristone in preinduction cervical ripening and induction of labour at term: an observational study(Medip Academy, 2023-11) Sahoo, Ipsita; Abichandani, RoshniBackground: Induction implies stimulation of uterine contractions before spontaneous onset of labour. It is indicated when the benefits to either mother or fetus outweigh those of pregnancy continuation. Of the various medical methods of induction, prostaglandins and oxytocin remain the most popular and acceptable methods in obstetric practice. Mifepristone is a steroid compound, with anti-progesterone activity. It increases uterine activity and causes cervical dilatation and effacement. We intend to study the role of oral mifepristone in preinduction cervical ripening and induction of labour in term pregnancies.Methods: In a prospective observational study carried out from Jan 2023 to June 2023 at a zonal hospital, 100 antenatal women at term with Bishop score less than 6 participated. Tablet mifepristone 200 mg single dose was given orally for induction. All patients were assessed after 24 hours for cervical ripening, need for augmentation, mode of delivery, maternal and neonatal outcome.Results: It was observed that there was a significant improvement in Bishop score 24 hours after giving mifepristone. Out of 100 women in the study, 82% delivered vaginally, 15% had caesarean section and 3% had instrumental delivery. 21% needed no second method of labour induction. 76% patients delivered within 48 hrs of ingestion of mifepristone. The majority of patients had good maternal and neonatal outcome.Conclusions: Mifepristone is an effective and safe method for preinduction cervical ripening and induction of labour in term pregnancies.Item Efficacy of single dose of misoprostol 800?g in the first trimester termination of pregnancy: a cross sectional study(Medip Academy, 2023-11) Dakpe, Ronald; Basanti, Namoijam; Singh, Yanglem Ajitkumar; Singh, L. BimolchandraBackground: The MTP (Amendment) Act 2021 has allowed termination of pregnancy up to 24 weeks on only certain indications. Decision of two medical practitioners are required for termination beyond 20 weeks. Misoprostol is one drug used for medical termination of pregnancy. It can be used alone in single or multiple doses, or in combination with other drugs. The study was undertaken to determine the efficacy of a single dose of 800 ?g of misoprostol in the first trimester pregnancy termination.Methods: It was a cross-sectional study conducted among 124 women in the first trimester who were undergoing termination of pregnancy. After administering 800 ?g of misoprostol vaginally, participants were kept under observation for 48 hours. Data were collected and analysed.Results: Around half of the participants (56.4%) expelled the conceptus completely by 12 hours, 78.2% by 48 hours. Seven (5.6%) out of those 27 failed cases were given further doses of misoprostol, while in the remaining 20 (16.1%), surgical intervention was undertaken.Conclusions: The efficacy of a single dose of misoprostol for 1st trimester termination of pregnancy varies widely from study to study, but, the efficacy increases with adding further doses of the same drug or addition of mifepristone. Misoprostol is a safe, cost effective, and reasonable drug for the termination of pregnancy in first trimester.Item Translation and validation of Marathi version of questionnaire for urinary incontinence diagnosis(Medip Academy, 2023-11) Pawar, Anushree M.; Ganvir, Shyam D.Background: Urinary incontinence is a common health problem among women, which affects the quality of life. knowledge about the risk factors of urinary incontinence in this population will help us to take measures to reduce the burden of the condition. Questionnaire for urinary incontinence diagnosis (QUID) helps to distinguish type of incontinence.Methods: It was a community based cross-sectional study involving women living in the rural areas. A total of 25 women were taken for this study to find out reliability and validity of Marathi version of this questionnaire. Data was analysed with statistical package for the social sciences (SPSS) 20.0.Results: The internal consistency (homogeneity) was evaluated by Cronbach抯 ? coefficient, which was 0.795. validation was obtained from expert panel and the pilot testing showed that the questionnaire is acceptable.Conclusions: QUID Marathi version has been proven a reliable and valid tool for assessing urinary incontinence in women. It can be used as a quick screening tool for urinary incontinence in women of rural population.