Transfusion-induced hemoglobinopathy in patients of beta-thalassemia major.
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Date
2011-07
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Abstract
Apparent hemoglobinopathy acquired after blood transfusion is an uncommon cause of diagnostic dilemma resulting in repeated testing and delay in the diagnosis. Out of the 1530 hemoglobin (Hb)- high-performance liquid chromatography (HPLC) performed at our hospital (May 2009 to April 2010), 3 pediatric cases of thalassemia major were detected having posttransfusion hemoglobinopathy with HbS ranging from 9.9% to 18.5%. In all three cases, there was no variant hemoglobin in earlier documented Hb-HPLC. It is important to be aware of and consider apparent transfusion-induced hemoglobinopathy in patients with unusual percentage of variant hemoglobin to avoid unnecessary treatment and counseling.
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Keywords
HbS, hemoglobinopathy, thalassemia major, transfusion
Citation
Gupta Sanjeev K, Sharma Monica, Tyagi Seema, Pati Hara P. Transfusion-induced hemoglobinopathy in patients of beta-thalassemia major. Indian Journal of Pathology & Microbiology. 2011 Jul-Sept 54(3): 609-611.