Histopathologic Correlation of ASC-US and ASC-H
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2010-04-06
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Thai Cancer Journal
Abstract
This descriptive study was designed to study the histopathologic correlation of atypical squamous cell in cervical smear at the National Cancer Institute from October 1,2005 to September 30,2007. Sixty-three cases of ASC-US were performed colposcopic biopsy and/or LEEP. The histologic diagnosis revealed low grade lesion or LSIL in 11 cases (17.4%), high grade lesion (HSIL or worse) 16 cases (25.4%), atypical squamous metaplasia 1 case (1.6%), and inflammation 35 cases (55.6%). In the category of ASC-H, 105 cases were performed colposcopy, which the histologic diagnosis revealed low grade lesion or CIN 1 in 21 cases (20 %), high grade lesion (CIN 2 or worse) 45 cases (42.9%), atypical squamous metaplasia 7 cases (6.7 %), and inflammation 32 cases (30.5 %). Cases classified as ASC-H are associated with a significant risk of high grade lesion than ASC-US category. However, this study assumed that patients with atypical squamous cell either ASC-US or ASC-H according to the 2001 Bethesda System classification should receive the proper management since they have an increase risk of underlying cervical intraepithelial neoplasia and rarely carcinoma.
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Thai Cancer Journal; Vol.28 No.1 January-March 2008; 44-47