Chronic Toxicity of Yahom Navagoth Extract
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Date
2010-07-07
Authors
Pranee Chavalittumrong
Songpol Chivapat
Aimmanas Attawish
Noppamas Soonthornchareonnon
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Department for Development of Thai and Alternative Medicine
Abstract
A Thai traditional recipe called yahom navogoth, has been used in the treatment of circulatory disorder symptoms. The recipe comprises 54 herbal plants and Borneol camphor. Acute toxicity of yahom navogothextract (NGE) was assessed in 50 ICR mice randomly divided into five groups of 10 mice each as follows: A control group was given distilled water orally and four experimental groups were orally administered with NGE at doses of 2, 4, 8 and 16 g/kg, respectively. NGE at doses of 2 and 4 g/kg did not cause any acute toxicsigns nor lethality, whereas doses of 8 and 16 mg/kg produced 10 and 70 percent mortality, respectively. Chronic toxicity study of yahom navogoth extract was performed in 144 Wistar rats divided into six groups of 24 rats each (12 males and 12 females). The control group was given distilled water and the five experimental groups were administered yahom navagoth extract orally at doses of 10, 100, 500, 1000 and 1000 mg/kg/day, respectively, for six months. The extract doses given to the animals were approximately equivalent to 1, 10, 50, 100 and 100 times larger than the human therapeutic dose. The last group was used for a recovery study after two weeks discontinuation of the highest dose. The result revealed that NGE did not affect body weight, food consumption, behavior and the general health of the animals. Male rats receiving NGE at 1000 mg/kg/day had a significant increase in total leukocytes and female rats receiving the same dose had a significant increase in platelet counts. However, these hematological values tended to decrease after withdrawal of the extract. NGE did not cause any abnormality of clinical chemistry values. The incidence of histopathological alterations in the NGE-treated groups did not show any dose dependence with the extract. In conclusion, yahom navagoth extract did not cause chronic toxicity in the Wistar rats.
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Journal of Traditional Thai \& Alternative Medicine; Vol. 7 No. 2-3 May-December 2009; 134-145