Mitomycin C induced inhibition of adrenal steroidogenesis in female rats.

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Date
1994-04-01
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Abstract
Mitomycin C (MC), an antibiotic which depresses DNA synthesis causes suppression of enzyme delta 5 3 beta-hydroxysteroid dehydrogenase (delta 5 3 beta OHD) and glucose-6 phosphate dehydrogenase (G-6 PD) in the rat adrenal tissue. The treatment resulted in a fall in DNA content together with an accumulation of cholesterol and ascorbic acid in the gland. The results suggest a diminution in adrenal steroid biogenesis similar to gonadal inhibition previously reported.
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Deb S, Koley BN, Deb C. Mitomycin C induced inhibition of adrenal steroidogenesis in female rats. Indian Journal of Physiology and Pharmacology. 1994 Apr; 38(2): 141-2
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https://imsear.searo.who.int/handle/123456789/106950
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Indian Journal of Physiology and Pharmacology