International Journal of Gastroenterology, Hepatology, Transplant & Nutrition
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Item Simultaneous presentation of autoimmune pancreatitis and ulcerative colitis: a case report(Society of Paediatric, Gastroenterology, Hepatobiliary, Transplant and Nutrition, 2018-06) Touibi, Youssef; Farouki, Ayman El; Africha, Taoufik; Zainoun, Brahim; Lamsiah, TaoufikAutoimmune pancreatitis type 2, an increasingly recognized etiology of pancreatitis in young patients without elevated IgG4. We report the case of a young woman admitted for acute pancreatitis, whose initial etiological record was negative. The evaluation of gravity by CT scan showed a slightly hipertrophic pancreas with the discovery of an aspect of ulcerative colitis "pancolitis". This association helped to guide the etiological diagnosis and treatment management. The patient was put on steroids with a rapidly favorable course, without recurrence and a 12-month follow-up.Item Dieulafoy’s Lesion – An unusual cause of acute abdominal pain in a child(Society of Paediatric, Gastroenterology, Hepatobiliary, Transplant and Nutrition, 2019-06) Pillai, Swapna K; Fhausiya, V.K; Shaji, S.M; Kailas, Lalitha; Sankar, Haritha Hari; John, Roshan JosephDieulafoy’s disease is a rare cause of abdominal pain and G I bleeding. A 10 year old girl having recurrent abdominal pain, GI bleeding and epistaxis. Ileal nodularity and prominent submucosal vessels seen in CT angiogram. Child underwent surgical treatment with favorable outcome. Diuelafoy’s disease can cause bleeding at multiple sites due to abnormal dilated vessels.Item Digestive involvement in retroperitoneal fibrosis(Society of Paediatric, Gastroenterology, Hepatobiliary, Transplant and Nutrition, 2018-06) Chabib, FZ; Moumayez, FZ; Elkhabiz, N; Benelbarhdadi, I; Ajana, FZRetro peritoneal fibrosis is a condition rarely seen in gastroenterology. Through these two observations and data from the literature we will address and focus on the digestive tract in the context of this disease and we will detail the different clinical aspects, radiological, pathological and therapeutic of this entityItem Assessment of auditory function in obese children(Society of Paediatric, Gastroenterology, Hepatobiliary, Transplant and Nutrition, 2018-12) Elsehmawy, Asmaa Abd El Wakeel; Ewida, Amal Mahmoud Hassan; Mohammed, Amal Gaber; Seliem, Nora Mohammed AhmedObesity is a chronic condition, associated with multiple comorbidities. Great attention has been paid to the obesity comorbidities such as cardiovascular disease and insulin resistance up to diabetes mellitus (T2DM), there’s evidence suggests that obesity affects hearing. The aim of the current study was to evaluate the relationship between obesity and hearing in a group of obese children. The present study was a controlled study that was carried out on 80 children of both genders and divided into study group, 40 healthy obese children, they were subdivided after the study has been completed into; group I, 26 healthy obese children with normal middle ear function. Group II 14 obese children with middle ear dysfunction. Control group included forty nonoverweight children. Our study revealed that there was significant increase of the pure tone threshold in obese children with middle ear affection in comparison to obese with normal middle ear and the control group. Positive correlation between pure tone with the anthropometric measures, lipid profile and insulin resistance in obese children with diseased middle ear. Cochlear affection in obese children with normal middle ear evidenced by a negative correlation between transient otoacoustic emission with the anthropometry, liver enzymes and insulin resistance. Obesity considered as a risk for conductive hearing loss and cochlear affection.Item Effect of simvastatin on the transforming growth factor β1, fibroscan scores, and aspartate transaminase to platelet index ratio patients with Liver Cirrhosis(Society of Paediatric, Gastroenterology, Hepatobiliary, Transplant and Nutrition, 2018-03) Kusnanto, P.; Prabowo, NA; Bambang, PBackground: Cirrhosis of the liver is the liver disorder marked fibrosis and abnormal liver architecture. Treatment of liver cirrhosis, among others, is to reduce fibrogenesis. Simvastatin as an anti-fibrotic among others, by a mechanism reduce the activity of hepatic stellate cell of the liver, reduce cell proliferation liver stelat, increases the production of nitric oxide and decrease vascular resistance in the liver cirrhosis. Aim: This research to determine effect of simvastatin on the transforming growth factor β1, fibroscan scores, and aspartate transaminase to platelet index ratio patients with liver cirrhosis. Methods: This study is a randomized experiment, a sample of 30 people, divided into a control group given a placebo and the treatment given simvastatin 20 mg / day orally for 4 weeks. Before and after treatment measured levels of TGF β1, FibroScan score, and a score of APRI. Statistical analysis using SPSS 22 for windows. Two different test mean using parametric tests (independent t test, paired t test) and if the data is normally distributed variable or non-parametric tests (Mann-Whitney / Wilcoxon Signed Rank Test). P significant if p <0.05. Results: The results showed that the administration of simvastatin 20 mg for 4 weeks will reduce levels TGF β1 (20,98+7,80 µg/dl pretreatment, 16,20+5,50µg/dl post treatment; p=0,013), reduce fibroscan scores (22,29+14,65 kpa pretreatment, 13,61+4,02 kpa post treatment; p=0,049) and reduce APRI scores (40,13+41,28 pretreatment, 23,41+17,61 post treatment; p=0,002). Conclusion: This study demonstrated that administration Simvastatin will be reduced levels of the transforming growth factor β1, fibroscan scores, and aspartate transaminase to platelet index ratio patients with liver cirrhosis.Item Surgical treatment in Strangulated Inguinal Hernia in Newborns and Infants(Society of Paediatric, Gastroenterology, Hepatobiliary, Transplant and Nutrition, 2018-03) Khamraev, AJ; Karimov, IM; Shamsiev, AFTo date, the gerontology pediatric treatment choice problem inguinal hernias in children continues to occupy a leading position in surgical operation, since it is one of the most common diseases in infants, especially up to 3 years. In cases where the hernia reduce a spontaneous, against the conservative child left the event in a hospital where the necessary investigations were carried out for further surgical treatment to "routinely". On the basis of its own historical and clinical data, analyzed the results of treatment of strangulated inguinal hernias in 50 newborns and infants. To prevent complications strangulated inguinal hernias in infants and premature babies play an important role technical aspects. The indications for the establishment of the Roux plastics in strangulated inguinal hernias in infants and babies were large hernia and prematurity. Postoperative complications have arisen in the form hematoma in 5.4% of cases and scrotal edema - 10%. The high position of the testis was observed in 2.5% of children. Management of pediatric surgeon strangulated inguinal hernias in infants and infants depends on timely diagnosis and timing of onset of the disease.Item Isolated rectal tuberculosis – a case report(Society of Paediatric, Gastroenterology, Hepatobiliary, Transplant and Nutrition, 2019-03) Nejjari, F.; Rouibaa, F.; Aomari, A.; Adioui, T.; Tamzaouarte, M.; Aourarh, A.Gastrointestinal tract (GIT) is commonly affected by tuberculosis; however isolated tuberculous involvement of the rectum is rare. A tuberculosis origin must be considered when the cause of perianal and rectal lesion is unclear to avoid delay in the diagnosis and treatment. We report an uncommon case of primary isolated rectal tuberculosis. Case report : Patient 45 years old, with no pathological history, who has been presenting low abundance hematochezia associated with abdominal pain, The rectoscopy is indicated, which showed a rectal ulcer at 8 cm from the anal margin, with erythematous mucosa. Multiple biopsies were performed, with the result of histological examination in favor of rectal tuberculosis. The search for mycobacterium tuberculosis by PCR technique (genexpert test) was positive. The patient was started on AntiKoch's Treatment (AKT) for six months. He responded very well to this anti tuberculosis therapy and after six months of follow-up he was completely asymptomatic. Conclusion : Rectal tuberculosis is a rare location difficult to diagnosis, usually improve after administration of an anti-bacillary treatment.Item Association of increased oxidative burden and excessive fluoride exposure in obese children(Society of Paediatric, Gastroenterology, Hepatobiliary, Transplant and Nutrition, 2018-09) Tomar, Balvir Singh; Nathiya, Deepak; Chauhan, Dushyant Singh; Tripathi, SandeepBackground: The modern scientific evidence representing that obesity associated with fluoride exposure may be a risk of reduced health quality in paediatric population. Obesity is an independent risk factor for cardiovascular diseases and markedly elevated risk of morbidity and mortality. Presence of higher levels of fluoride in drinking water (>1.5ppm) may be serious problems in health of the obese children. In the state of Rajasthan, almost all districts have high fluoride (up to 18.0 ppm) in their drinking / ground water sources. An estimated 66.6 million people (17 states in India) including 6 million less than 14 years children are at risk Aim: The aim of the present study was to evaluate the effect of fluoride in obese child of high endemic fluoride areas. Method: In the present study, we selected 54 obese children from the selected area of Jaipur- India, twenty seven children (n=27) from high fluoride (F > 2.5ppm) region and twenty seven (n=27) obese children (disease control) from, where fluoride content was normal (F< 1.5ppm) in their source of drinking water. Moreover, age matched healthy controls were selected from the Jaipur district where fluoride content in water was less than 1.5 ppm. After clinical examination, lipid profiles, oxidative stress parameters namely, lipid peroxide level (LPO), superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and reduced glutathione content. Results: The concentration of fluoride in serum was significantly correlates with their water concentration. Increased LPO levels and reduced antioxidant status in obese and fluoride exposed obese. Moreover, obese and fluoride exposed obese were more comparable. Conclusion: On the basis of the results it may conclude that fluoride enhances the severity of disease and fluoride promotes oxidative stress in obese paediatric population. However, further in depth of studies is required for the understanding of pathophysiology of child obesity those residing in endemic area of fluoride.