Indian Journal of Dermatology, Venereology and Leprology
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Browsing Indian Journal of Dermatology, Venereology and Leprology by Subject "5-Fluorouracil"
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Item Successful treatment of metastatic extramammary Paget's disease with pemetrexed monotherapy systemically and 5-fluorouracil topically(Indian Association of Dermatologists, Venereologists & Leprologists, 2019-01) Chen, Kexu; Liang, Hanlin; Peng, Jiewen; Zheng, YanfangAdvanced extramammary Paget's disease does not have a standardized treatment guideline as its incidence is low and has been rarely reported in literature. Here we describe a case of metastatic extramammary Paget's disease successfully treated with topical 5-fluorouracil (5-FU) and systemic pemetrexed. The therapy was safe without any appreciable adverse effects like diarrhea, rash, neutropenia or fatigue; maintaining remission for more than 6 months. Thus, we propose 5-FU and pemetrexed as the first-line therapy for advanced extramammary Paget's disease, especially for aged patients with unresectable skin lesions.