Indian Journal of Leprosy
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Item Acid fast bacilli in lymph node aspirate and smears from ear lobules and fingers in long treated patients.(1984-01-01) Kumar, B; Kaur, S; Gupta, S K; Rajwanshi, A; Darshan, HSkin slit smears from fingers and ear lobules and lymph node aspiration smears stained with Ziehl-Neelsen stain were studied in 43 patients of LL or BL disease. All the patients had taken dapsone monotherapy for 3-7 years. None of the patients had clinical evidence of dapsone resistance. Small number of bacilli were detected in 16 patients. Lymph node aspirate was positive in 5 cases, whereas ear lobule and fingers yielded bacilli in 12 and 13 cases respectively. It is recommended that in addition to the traditional ear lobe it is imperative to study other sites as well. Study from fingers is recommended for the sake of simplicity. Where facilities are available sampling of the lymph node may also be attempted to advantage.Item Dopa-oxidase activity on ICRC bacilli.(1984-01-01) Kale, V P; Bhat, A V; Bapat, C VPresence of O-phenoloxidase is regarded as M. leprae specific character. This enzyme activity was found to be present in ICRC bacilli, Strain C-44. Though this strain is cultivable 'in vitro', the expression of DOPA-Oxidase activity strongly suggests that it carries M. leprae genome. The ICRC bacilli, therefore, may thus from a group of M. leprae culture isolates, distinct from other known cultivable mycobacteria which do not possess this enzyme activity.Item Experience with two drug regimen in paucibacillary leprosy--preliminary report.(1984-01-01) Kaur, S; Sharma, V K; Kumar, B; Kaur, IItem Leprosy work in Sangal Pargana disrict of Bihar.(1984-01-01) Dharmendra,Item Once monthly rifampicin (1200 mg) plus daily dapsone (100 mg) and clofazimine (100 mg) in the initial treatment of lepromatous leprosy.(1984-01-01) Chandorkar, A G; Burte, N P; Gade, R K; Bulakh, P MThe therapeutic effect of rifampicin 1200 mg once monthly and 100 mg clofazimine daily for the first six months of treatment was evaluated in 30 patients of bacteriologically positive lepromatous leprosy patients. Moderate to marked clinical improvement was seen in all the patients and a very rapid bacteriological regression as indicated by the decrease in bacteriological and morphological indices of the skin within one week. Seven patients become MI negative at one month and three months and 13 at the end of nine months. Two patients became MI and BI negative at the end of six months and six at the end of nine months. These observations clearly establish the high therapeutic efficacy and practicability of the three drug regimen. Once monthly rifampicin is highly effective and well tolerated, and has many advantages like low cost, better patient compliance and reliability of the treatment. Addition of clofazimine to rifampicin and dapsone prevents the emergence of E.N.L. reactions which were seen during treatment with once monthly rifampicin and daily dapsone. This regimen is thus ideal for initial, intensive treatment of lepromatous leprosy and may help in preventing the spread of the disease and development of dapsone resistance.Item A study about the billboards on leprosy displayed in the Pallavan Transport Corporation buses at Madras City.(1984-01-01) Cheriyan, C S; Roopkumar, K SItem Lepromin-H versus lepromin-A.(1984-01-01) Kumar, B; Kaur, S; Sharma, V K; Kaur, IItem Multi-drug therapy in leprosy: an effective method of control.(1984-01-01)The steady increase in the prevalence of dapsone-resistant strains of leprosy threatens to undermine all the advances thus made for the control of this disease. Adoption of multidrug therapy, which can reverse this trend, is urgent.Item Alanine dehydrogenase in mycobacteria--a preliminary report.(1984-01-01) Kannan, K B; Katoch, V M; Bharadwaj, V P; Sharma, V D; Dutta, A K; Venkatesan, KVarious mycobacterial species namely M. phlei, M. vaccae, M. scrofulaceum, M. avium and M. tuberculosis have been investigated for the presence of enzyme alanine dehydrogenase which could be important for utilization of alanine by TCA cycle. It was found that alanine dehydrogenase was present in all species of mycobacteria tested irrespective of the fact whether they are rapid or slow growers. Electrophoretic mobilities of alanine dehydrogenase from different species of mycobacteria were not found to be significant for taxonomical differentiation of rapid and slow growers.Item The mouse footpad test--sensitive to small proportions of drug-resistant bacilli in a sample of M. leprae.(1984-01-01) Almeida, J G; Joseph, P S; Sarangapani, G; Chacko, C JIn experiments at the Radda Barnen Research Laboratories of the SLR & TC Karigiri, the mouse footpad test was demonstrated to detect DDS-resistant M.leprae even if as few as 0.1% (1 in 1000) of the M. leprae tested were DDS-resistant. The mouse footpad test appears to be sensitive to minute proportions of drug-resistant bacilli in samples of M. leprae tested.Item Health Management Information System in Leprosy Control Programme.(1984-01-01) Yellapurkar, M VHealth Management Information System was introduced methodically and enforced with ruthless punctuality in Maharashtra State from April 1981. It has paid excellent dividends so far as the implementation of the National Leprosy Control Programme is concerned. Key indicators have been fixed for new case detection, bacteriological examination, regularity of treatment and screening of old patients for activity status. Monitoring of these activities is done regularly and a feed back is provided. Marks are assigned for each kidney indicator and ranking is done based on the achievement of targets by each district, Municipal Corporation, Health Circle etc., every month. The same procedure is adopted at Primary Health Centre and even lower level. This has introduced a spirit of competition and generated a desire to better one's own performance by identifying and removing deficiencies. Maximum assistance is being derived from the Primary Health Care and use is being made of Multi Purpose Workers, Community Health Volunteers and other anciliary agencies in case finding and case holding programmes. The improvement in performance in respect of all key indicators during 1981-82 has been between 40 and 60 percent over the performance during 1980-81.Item Evaluation of audiovestibular status in leprosy.(1984-01-01) Singh, T R; Agrawal, S K; Bajaj, A K; Singh, R K; Singh, M MOne hundred twenty five cases of lepromatous leprosy and 25 cases of tuberculoid leprosy were investigated for audiovestibular status. Impaired hearing was detected in 52 percent and vestibular hypofuction in 7.2 per cent of lepromatous cases. Conductive deafness was due to eustachian tube catarrh secondary to atrophic rhinitis associated with the disease. The perceptive deafness and vestibular hypofuction were due to end organ lesion probably due to E.N.L. reaction. The vestibulococlear nerve involvement was considered to be unlikely. In tuberculoid leprosy derangement in hearing was not observed in any cases.Item Evaluation of multidrug therapy with rifampicin, clofazimine and D.D.S. in multibacillary leprosy cases.(1984-01-01) Kundu, S K; Hazra, S K; Chaudhury, S; Chatterjee, BRifampicin, Clofazimine and D.D.S. have been tried in fifteen active untreated lepromatous cases for a period of two years. Compared to dapsone monotherapy remarkable clinical and bacteriological improvement was observed with this combined therapy with attainment of negative BI in ten cases. Use of this combination therapy is thus advocated to achieve noninfectivity in a shorter period and to prevent emergence of dapsone resistance thereby causing the path of leprosy control before it becomes unmanageable due to dapsone resistance.Item Human vaccination studies in normal and contacts of leprosy patients.(1984-01-01) Samuel, N M; Stanford, J L; Rees, R J; Fairbairn, T; Adiga, R BItem "Leprosy in India" becomes "Indian Journal of Leprosy".(1984-01-01) Dharmendra,Item Repositioning of pupil for visual disability.(1984-01-01) Lamba, P A; Santoshkumar, DThe authors have successfully utilised the technique of photocoagulation of iris in 35 cases for improving the visual acuity in cases suffering from ocular leprosy. The photocoagulation was considered to be very useful in cases with corneal scars, highly vascularised adherent leukomas, where keratoplasty stands a poor risk. It has also been recommended for cases with pinpoint pupil not dilating with drugs for diagnostic and prognostic value.Item Immunological studies in leprosy--II: Study of lymphoblast transformation to PHA in different types of leprosy patients.(1984-01-01) Singh, P K; Ratna,; Jain, P K; Mital, V PNinety cases of different types of leprosy were studied for lymphoblast transformation response using PHA-M. The difference of percentage was statistically analysed and found to be highly significant when total leprosy cases were compared with control cases and with different types of leprosy cases (P = less than .005), except control and TT where it was significant only (P = less than .05). The difference between TT and other types was also calculated and has been observed to be highly significant (P = less than .005). There was gradual decrease in lymphoblast transformation percentage from tuberculoid pole to lepromatous pole.Item An epidemiological study of leprosy in a rural community of Pondicherry.(1984-01-01) Reddy, B N; Bansal, R DIn a rural area, endemic for Leprosy a total population survey had been undertaken in 6 villages covering a population of 5667. Out of the 5281 persons examined, 191 were found to be suffering from leprosy giving a prevalence rate of 36.16/1000. The prevalence was highest in children aged between 5 and 14 years., i.e., 41.61/1000. Among adults the highest prevalence was seen among those aged above 45 years, i.e., 45.66/1000. Both the sexes were found to be equally affected in this area. Tuberculoid leprosy was the most common type found with a prevalence rate of 23.29/1000, followed by Indeterminate type with a prevalence rate of 5.3/1000. Lepromatous rate was 3.69%. The disability rate was found to be 16.23%, with a mean disability index of 0.927.