Browsing by Author "Watanabe, Hisami"
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Item Pyrimethamine-sulfadoxine treatment of uncomplicated Plasmodium falciparum malaria in Lao PDR.(2005-09-28) Mannoor, M Kaiissar; Vanisaveth, Viengxay; Keokhamphavanh, Boualy; Toma, Hiromu; Watanabe, Hisami; Kobayashi, Jun; Hatabu, Toshimitsu; Taguchi, Nao; Hongvangthong, Bousy; Phetsouvanh, Rattanaxay; Phompida, Samlane; Kano, Shigeyuki; Sato, YoshiyaA 28-day in vivo treatment trial to evaluate the efficacy of pyrimethamine/sulfadoxine (Fansidar, PS) was conducted in 21 Lao patients with uncomplicated Plasmodium falciparum malaria. Sixteen patients (76%) were completely cured with PS without any reappearance of asexual stage parasitemia during the follow-up examination. On the other hand, 5 patients (24%) failed to respond to this trial medication, resulting in recrudescence of asexual stage P. falciparum malaria. PS resistance resulted in higher prevalence of post-treatment gametocytemia, 25% gametocyte carriers among PS sensitive cases versus 75% of the resistant cases. These findings suggest that although the level of PS resistance is still valid for treatment of malaria in the study area of Lao PDR, post-treatment induction of gametocytemia among resistant cases may result an increase in transmission rate of PS resistant falciparum malaria.