Browsing by Author "Shukla, V J"
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Item A comparative study on different market samples and standard samples of Shalaparni through physicochemical methods and near infrared spectroscopy.(2014-10) Raval, Parth; Patel, B R; Shukla, V J; Patil, Bhavesh; Parmar, Neha; Pandya, Preeti; Bhardwaj, ShivangiDashmoolais one of the most important groups explained in Mishrakagana. One of which, Shalaparni is a potent drug used single as well as in various formulations mentioned in classics. Adulteration in Dashmoolaplants is a very big issue now days and this is because of the lack of availability of the original drugs. In this study market samples of Shalaparni (Desmodium gangeticum DC.) collected from the different part of India; compared with the standard Shalaparni authenticated sample which was collected from the natural source; by using physicochemical parameter and near infrared spectroscopy. Results were statistically processed by PCA. The results show that there is no similarity found outbetween the standard drug and market samples of Shalaparni which were collected from different regions of India. The market samples were observed for different adulterated material having poor quality.Item Comparitive Pharmacognostical and Phytochemical Evaluation of Brihat and Laghu Gokshur.(2012-08) Renuka; Khanpara, Komal; Shukla, V J; Prajapati, P K; Harisha, C R; Pandiya, PreetiLaghu Gokshur (Tribulus terrestris) and Brihat Gokshur (Pedalium murex) are well known drugs used in Ayurveda as diuretics. These are classified under mishrak varga as ‘Dashmoola’ in Ayurveda and in chemotaxonomy as Saponin glycosides. The objective of the work is to find out the diagnostic tool to identify the two varieties of Gokshur. The powder was studied for macroscopic, microscopic and physicochemical parameters. For HPTLC Stationary phase was Pre-coated silica gel GF 254 and mobile phase was Toluene: Ethyl acetate: Formic acid (7:2:1 v/v/v). The plate was scanned and quantified at 254 nm for Diosgenin.Results shows that microscopic characters like trichomes, stomata and crystals show some difference in the two varieties while physicochemical parameters show difference in extractive values. Phytochemical screening also shows similar findings. HPTLC analysis carried out using Diosgenin as reference standard revealed the presence of steroidal Saponin “Diosgenin”. Quantitative estimation for Saponins found marked variation in the two varieties, where Laghu gokshur had 16% of Saponins while Brihat gokshur had 13% Saponins. The study can be used as a diagnostic tool for identification of these two varieties of Gokshur.Item General pharmacology of Vitex leucoxylon Linn leaves.(1994-04-01) Makwana, H G; Ravishankar, B; Shukla, V J; Nair, R B; Vijayan, N P; Sasikala, C K; Saraswathy, V N; Bhatt, S VEthanol extract (ETE) and cold aqueous infusion (CAI) of Vitex leucoxylon leaf were evaluated in a battery of tests to define the activity profile of the plant. CAI depressed SMA, antagonised d-amphetamine stereotypy and oxotremorine tremors, shortened the duration of mice immobility in behavioural 'despair' test and lowered serum total cholesterol level. ETE showed significant inhibition of carrageenin paw oedema and granulation tissue formation in rats. Suppression of acetic acid writhing was observed with both ETE and CAI. LD50 value of ETE was > 3000 mg kg-1 (ip) and that of CAI 1050 (800-1200) mgkg-1.Item Immunomodulatory activity of guduchi ghana (aqueous extract of tinospora cordifolia miers).(2013-05) Umretia, Bharti; Vaishnav, P U; Patgiri, B J; Prajapati, P K; Shukla, V J; Ravishankar, BIn the present work, Guduchi Ghana (concentrated form of aqueous extract of Guduchi) was prepared according to the method described in classical text – Sidhdha Yoga Samgraha and the other sample of aqueous extract was purchased from the market for the assessment of the immunomodulatory activity. It was done by haemagglutination antibody titre method for humoral immunity and footpad swelling method for cell mediated immunity on wistar albino rats. Results of present studies suggest that Guduchi Ghana prepared by classically was found to possess significant immunostimulatory action on immune system but market sample of it exhibited significant immunosuppression effect in dose dependent manner when compare with control group at a dose of 50 mg/kg orally.Item Micro evolution of bitter taste domain drugs.(2014-07) Bhardwaj, Shivangi; Shukla, V J; Harisha, C R; Jani, SwituAyurveda classified the drugs in various ways and one of which the classification is based on Rasa (taste) dominancy. Rasa is essential to identify drugs and to know its therapeutic application. In this study the drug has been selected according to Charaka classification of Tikta Rasa (bitter taste) drugs with an aim to find out the similar characters among all the drugs having bitter Rasa dominancy. Till date there is no data available regarding the pharmacognostical evaluation in concern bitter taste. For the first time selected five bitter drugs are subjected to various pharmacognostical evaluation, result reveals that Organoleptic characters of all five drugs give bitter taste, microscopic evaluation revealed that presence of starch grain, vessels, fiber , brown content are dominant in all five raw drug and all the five powder subjected to alkaloid test by using dragondroff reagent and give positive result for alkaloids.Item Pharmacognostical and physicochemical analysis of Tamarindus indica Linn stem.(2012-01) Kodlady, Naveena; Patgiri, B J; Harisha, C R; Shukla, V JTamarindus indica Linn. fruits (Chincha) are extensively used in culinary preparations in Indian civilization. Its vast medicinal uses are documented in Ayurvedic classics and it can be used singly or as a component of various formulations. Besides fruit, the Kasta (wood) of T. indica L. is also important and used to prepare Kshara (alkaline extract) an Ayurvedic dosage form. Pharmacognostical and physicochemical details of Chincha Kasta are not available in authentic literature including API (Ayurvedic Pharmacopoeia of India). The study is an attempt in this direction. T. indica L. stem with heartwood was selected and morphological, microscopic and physicochemical standardization characters along with TLC fi nger print, and fl uorescence analysis were documented. Transverse section of stem showed important characters such as phelloderm, stone cells layer, fi ber groups, calcium oxalate, crystal fi bers, and tylosis in heartwood region. Four characteristic spots were observed under UV long wave, in thin layer chromatography with the solvent combination of toluene: ethyl acetate (8:2). The study can help correct identifi cation and standardization of this plant material.