Browsing by Author "Shukla, M M"
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Item Effectiveness of alpha-beta arteether in clearing Plasmodium falciparum parasitemia in central India (Madhya Pradesh).(1998-06-14) Singh, N; Shukla, M M; Asthana, O P; Sharma, V PForty-six patients (25 Females + 21 Males) of uncomplicated Plasmodium falciparum in districts Jabalpur and Mandla of central India (Madhya Pradesh) were administered alpha-beta arteether (an ethyl derivative of qinghaosu), intramuscularly for 3 consecutive days (150 mg once a day). The results revealed that there was rapid control of fever in all the patients without administration of any antipyretic drug. The mean parasite clearance time was 30.78 +/- 10.92 hours and recrudescence/reinfection rate was 6.7% within 28 days. Study indicates that arteether, besides being a potent and fast acting schizontocidal drug, also exhibited gametocytocidal action on P. falciparum.Item Efficacy of alpha, beta - Arteether in children with cerebral malaria in forested tribal belt.(2002-06-27) Shukla, U K; Damle, R K; Shukla, M M; Singh, NItem A multicentric study with arteether in patients of uncomplicated falciparum malaria.(2001-07-28) Asthana, O P; Srivastava, J S; Kamboj, V P; Valecha, N; Sharma, V P; Gupta, S; Pande, T K; Vishwanathan, K A; Mahapatra, K M; Nayak, N C; Mahapatra, P K; Mahanta, J; Srivastava, V K; Vasdev,; Singh, N; Shukla, M M; Balsara, A B; Mishra, S K; Satpathy, S K; Mohanty, S; Dash, BTwo hundred and sixty seven patients of uncomplicated P. falciparum malaria completed study in a multicentric phase III clinical trial of Arteether. Arteether was given intramuscularly in a dose of 150 mg daily for three consecutive days. Each patient was followed upto 28 days of alpha, beta arteether therapy. The cure rate was 97% with fever clearance time between 1-7 days (24-168 hours) and parasite clearance time between 1-3 days (24-72 hours). Parasite reappearance rate was found to be 3% and reported at only three of the centres. Following the treatment no adverse effect was observed on haematological, biochemical and vital clinical parameters.Item Sociocultural barriers to accepting malaria chemoprophylaxis by pregnant women in central India.(2002-03-23) Singh, Neeru; Shukla, M M