Browsing by Author "Sharma, A"

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    An abnormal LDH isoenzyme band in myocardial infarction: a case report.
    (1980-09-01) Swain, B K; Talakdar, G; Sharma, A
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    Abnormal morphological appearance of Klebsiella pneumoniae in blood culture: A microscopic observation
    (Indian Association of Pathologists and Microbiologists, 2018-12) Saurabh, K; Nag, VL; Sharma, A; Maurya, AK; Hada, V
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    Achalasia cardia.
    (2000-02-01) Rattan, K N; Sharma, A
    Achalasia cardia is an uncommon condition in children. It needs special consideration as it is associated with a higher incidence of recurrent respiratory infection and failure of growth and development, thereby requiring an early surgical intervention. Four such cases who were successfully managed surgically are described.
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    Activity of bacterial phosphomonoesterases in batch culture.
    (1998-01-16) Sharma, A; Gaikwad, S; Rajput, S
    The phosphomonoesterases catalyse the hydrolysis of primary esters of phosphoric acid which help the bacteria to survive in phosphate stressed environment. Ninety-five bacterial isolates were obtained from domestic sewage and industrial effluents of gelatine and soap factories at Jabalpur on a medium enriched with phosphate and were screened for phosphatase production. The phosphatase producers were tentatively identified as Escherichia coli, Vibrio vulnificus, Aeromonas hydrophila, Staphylococcus aureus, Pseudomonas maltophilia and Micrococcus varians. The in vitro studies on the production of phosphomonoesterases by bacteria was conducted. The maximum alkaline phosphatase production was recorded on 8th day of incubation by E.coli and P.maltophilia, on 10th day of incubation by V.vulnificus while M.varians and P.maltophilia produced higher acid phosphatase on 4th and 10th day of incubation respectively. The detailed investigations were done to find out the effect of various physical and chemical factors on phosphomonoesterases activity and the optimum conditions required for enzyme activity.
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    Acute alcoholic myopathy, rhabdomyolysis and acute renal failure: a case report.
    (2000-03-07) Singh, S; Sharma, A; Sharma, S; Sud, A; Wanchu, A; Bambery, P
    A case of middle aged male who developed swelling and weakness of muscles in the lower limbs following a heavy binge of alcohol is being reported. He had myoglobinuria and developed acute renal failure for which he was dialyzed. Acute alcoholic myopathy is not a well recognized condition and should be considered in any intoxicated patient who presents with muscle tenderness and weakness.
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    Acute promyelocytic leukemia: An experience from a tertiary care centre in north India.
    (2011-07) Bajpai, J; Sharma, A; Kumar, L; Dabkara, D; Raina, V; Kochupillai, V; Kumar, R
    Background: There are very limited data reported about acute promyelocytic leukemia (APL) from developing countries. We reviewed the clinical course and treatment outcome of APL patients treated at our center. Materials and Methods: Between January 1997 and December 2007, 33 patients with APL received induction therapy using ATRA + daunorubicin (n = 26), As = 26), As2O3 (n = 4) or daunorubicin + cytosar ( n = 3). Results: Median age was 30 years with a male to female ratio of 1.68. Twenty seven patients (82%) achieved CR. Complications during induction therapy were febrile neutropenia (33%), ATRA syndrome (30%), bleeding (58%), and diarrhea in (6%) patients. During induction and follow up, 8 (24.24%) patients died, 6 (18.18%) during induction, 1 (3%) during maintenance, and 1 (3%) after relapse. Median OS is 128 months while median EFS is 61 months. Four patients relapsed at a median time of 61 months. At the time of censoring, 25 patients were alive at a median follow up of 13 months (range 0.6 -127 months); 21 in CR1, 3 in CR2, 1 in CR3. Comparisons among the risk groups (CR and relapse rate and survival statistics) were not statistically significant. Conclusions: APL is a highly curable malignancy. Our results confirm the findings of the published literature from larger cooperative studies from the West. We may further improve outcome with quicker diagnosis and more efficient supportive care system.
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    Acute superior mesenteric vein thrombosis associated with factor V 'Leiden' gene mutation.
    (2003-06-23) Shah, S R; Gupta, A D; Sharma, A; Joshi, A; Desai, D; Abraham, P
    OBJECTIVES: To study thrombophilia states in Indian patients with acute spontaneous superior mesenteric vein thrombosis (SMVT). METHODS: Two men with this condition, a 56 year old and a 31 year old presenting with acute SMVT, demonstrated on CT scan, were subjected to a thrombophilia screen consisting of Protein C, S, antithrombin levels, lupus anticoagulant, anticardiolipin antibodies, fibrinogen levels, factor VIII levels, factor V 'Leiden' gene mutation, and paroxysmal nocturnal hematuria screen. RESULTS: A thrombophilia screen showed factor V 'Leiden' gene mutation (heterozygous) in both cases. Additionally, the first patient had high fibrinogen levels and the second high factor VIII levels. Both patients are currently on long-term anticoagulation. CONCLUSION: Factor V 'Leiden' gene mutation in association with other thrombophilic factors may predispose to spontaneous superior mesenteric vein thrombosis.
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    Acyclovir in paediatrics.
    (1994-02-01) Sharma, A
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    Adrenocortical involvement in aluminium phosphide poisoning.
    (1989-08-01) Chugh, S N; Ram, S; Sharma, A; Arora, B B; Saini, A S; Malhotra, K C
    The effect of aluminium phosphide (AlP) which is a systemic poison on the adrenal cortex was studied in 30 patients of AlP poisoning. A significant rise in the plasma cortisol level (greater than 1048 nmol/l) was observed in the twenty patients. Mortality was 50 per cent. Autopsy study could be undertaken only in 10 patients. Histopathology showed mild to moderate changes. In the rest (10 patients), the adrenal cortex was critically involved and the cortisol level failed to rise beyond normal levels (less than 690 nmol/l). The histopathology revealed severe changes (complete lipid depletion, haemorrhage, necrosis etc.) and all these patients died. In the critically ill patients, the cortisol levels remained low because of severe adreno-cortical involvement. The changes in the adrenal cortex could be due to shock or to cellular toxic effect of phosphine. The histopathological changes in various viscera showed congestion, edema and cellular infiltration. In the heart, there were patchy areas of necrosis, while the liver showed fatty changes and the lungs showed, in addition areas of gray/red hepatization. There was no adrenal apoplexy or extensive haemorrhage that could explain shock in these patients. Cardiogenic shock could not be confirmed due to lack of facilities for haemodynamic monitoring, but there was histopathological evidence in support of cardiovascular shock.
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    Age-related changes in macular vessels and their perfusion densities on optical coherence tomography angiography
    (All India Ophthalmological Society, 2020-03) Pujari, A; Chawla, R; Markan, A; Shah, P; Kumar, S; Hasan, N; Sharma, A; Kumar, A
    Purpose: To evaluate age-related changes in macular vessels and their perfusion densities using optical coherence tomography angiography (OCTA). Methods: A total of 108 eyes of 54 healthy subjects between the age group of 11 to 60 years having unaided visual acuity of 20/20 were studied on spectral domain OCTS using 3 * 3 mm macula protocol. These subjects were divided into 5 groups; Group 1: 11–20 years, Group 2: 21–30 years, Group 3: 31–40 years, Group 4: 41–50 years, and Group 5: 51–60 years. An early treatment diabetic retinopathy study (ETDRS) grid overlay at the macula was used to calculate changes in different quadrants of the superficial retinal plexus. Results: A total of 98 eyes of 49 patients were considered for the final analysis. The vessel density values decreased from the second to the sixth decade in all four quadrants (except the third decade, where a slight increase was noted). The total vessel density decreased from 168 ± 78 mm-1 (group 1) to 131.47 ± 18.32 mm-1 (group 5). A similar reduction pattern in perfusion density was seen in each quadrant from the second to the sixth decade. The total perfusion density reduced from 309 ± 15.63% (group 1) to 283.05 ± 45.23% (group 5). The foveal avascular zone area was 0.18 ± 0.09 mm2 in group 1, 0.33 ± 0.13 mm2 in group 2, 0.30 ± 0.10 mm2 in group 3, 0.38 ± 0.05 mm2 in group 4, and 0.46 ± 0.06 mm2 in group 5. Conclusion: In our population, macular vessel density appears to decrease noticeably from the fourth decade onwards but a statistically significant decrease was observed only from the fifth decade onwards. However, it was not uniform along with all the quadrants. Similarly, the percentage of perfusion density dropped from the fourth decade but these values also varied among the different quadrants.
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    Alexander's disease: a case report of a biopsy proven case.
    (1999-12-08) Tatke, M; Sharma, A
    A case of infantile onset Alexander's disease in a two and a half year old male child is presented, who had progressively increasing macrencephaly since birth. A frontal lobe biopsy revealed collections of Rosenthal fibres in the subpial and perivascular areas with diffuse dysmyelination and presence of reactive astrocytes. The Rosenthal fibres were immunoreactive for glial fibrillary acidic protein and ubiquitin. Electron microscopic examination showed the Rosenthal fibres as intra-astrocytic and extracellular granular osmiphilic collections.
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    Anemia in protein-energy malnutrition.
    (1985-11-01) Sharma, A; Sharma, S K; Grover, A K; Tewari, A D; Abrol, P
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    Angiomatoid fibrous histiocytoma: Report of two cases, initially construed as sarcoma with unusual clinico-pathological features
    (Wolters Kluwer - Medknow, 2022-12) Pasricha, S; Durga, G; Sharma, A; Pruthi, M; Kamboj, M; Gupta, G; Jajodia, A; Mahawar, V; Babu Koyyala, VP; Mehta, A.
    Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of uncertain differentiation with low metastatic potential, most commonly occurring in children, adolescents, and young adults, involving extremities. Due to its rare nature and diverse presentation, both clinically and morphologically, it is often misdiagnosed. It becomes important to correctly diagnose this lesion, given its distinct therapeutic implications. Here, we present the clinical, radiologic, and pathologic findings of two rare cases of AFH. Since AFH is a rare soft tissue tumor with low malignant potential, both pathologists and clinicians should be aware of this entity, when encountered with a soft tissue mass in extremities of a child or adolescent, so as to accord appropriate treatment in such cases.
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    Annular pancreas in elderly male: a case report
    (Medip Academy, 2023-05) Thakur, T; Sharma, A; Thakur, N.
    Annular pancreas (AP) is a rare congenital abnormality in which the ventral portion of the pancreas fails to rotate with the duodenum during embryological development, thus causing the ventral portion to remain partially or fully enveloped around the duodenum. The actual incidence of AP is unknown, as many cases are asymptomatic and undiagnosed. Adults with AP may present with a variety of symptoms suggestive of gastric outlet obstruction, or may present with gastrointestinal bleeding, pancreatitis, or biliary obstruction. Surgery continues to remain the diagnostic “gold standard” for AP, but imaging techniques such as CT, MRCP (Magnetic resonance cholangiopancreatography), ERCP (Endoscopic retrograde cholangiopancreatography) and EUS (Endoscopic ultrasound) can now be used to make the diagnosis. We report the case of a 65-year-old gentleman who presents with symptoms of gastric outlet obstruction who was diagnosed with AP by CECT (Contrast enhanced computed tomography) and MRCP.
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    Anthropometric measurements and physical characteristics in the assessment of neonatal maturity.
    (1975-09-01) Sharma, A; Dhatt, P S; Verma, K C; Gupta, H L; Singh, H
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    Anti-ganglioside antibodies in patients with Guillain Barré syndrome and other neurological disorders.
    (2013-04) Vaishnavi, C; Behura, C; Prabhakar, S; Sharma, A; Kharbanda, P
    A study was performed on 59 Guillain-Barré syndrome (GBS) cases, 58 neurological controls (NC) and 60 non-neurological controls (NNC) to investigate the association of anti-ganglioside antibodies in GBS and other neurological disorders. Campylobacter jejuni was isolated from 5.7% of GBS patients. Anti-ganglioside immunoglobulin G was present in 82% and immunoglobulin M in 46% in acute inflammatory demyelinating polyneuropathy patients, 70% and 44% respectively in acute motor axonal neuropathy subgroup and 38% each in acute motor sensory axonal neuropathy subgroup. Though high intensity of anti-gangliosides was present in the GBS patients, the NC patients also had adequate anti-gangliosides compared with the NNC group.
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    The anti-idiotype network in systemic lupus erythematosus--a review.
    (1994-05-01) Badakere, S S; Sharma, A
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    Antithrombin III assay using thrombin in disseminated intravascular coagulation (DIC), other thromboembolic disorders and hepatic diseases.
    (2004-04-22) Saxena, V; Mishra, D K; Subramanya, H; Satyanarayana, S; Sharma, A
    Fifty cases comprising 11 cases of disseminated intravascular coagulation (DIC), 16 cases of venous thromboses and 23 cases of hepatic diseases were studied for AT III levels using clotting assay. Twelve samples were subjected to ATIII estimation by the commercially available synthetic chromogenic assay. Twenty age and sex matched controls were also analysed to find out the reference value for the techniques. Low AT III levels, if present, were correlated with other markers of DIC, viz FDP and D-dimer assays. There was a decrease in the AT III levels in all the three disease categories with a significant difference between the AT III levels of the three disease categories. In DIC, lowest levels were observed which correlated well with FDP and D-dimer levels. There was no significant difference between the average AT III levels measured by both the clotting and synthetic chromogenic assay with the former procedure being relatively inexpensive.