Acute superior mesenteric vein thrombosis associated with factor V 'Leiden' gene mutation.
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2003-06-23
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Abstract
OBJECTIVES: To study thrombophilia states in Indian patients with acute spontaneous superior mesenteric vein thrombosis (SMVT).
METHODS: Two men with this condition, a 56 year old and a 31 year old presenting with acute SMVT, demonstrated on CT scan, were subjected to a thrombophilia screen consisting of Protein C, S, antithrombin levels, lupus anticoagulant, anticardiolipin antibodies, fibrinogen levels, factor VIII levels, factor V 'Leiden' gene mutation, and paroxysmal nocturnal hematuria screen.
RESULTS: A thrombophilia screen showed factor V 'Leiden' gene mutation (heterozygous) in both cases. Additionally, the first patient had high fibrinogen levels and the second high factor VIII levels. Both patients are currently on long-term anticoagulation.
CONCLUSION: Factor V 'Leiden' gene mutation in association with other thrombophilic factors may predispose to spontaneous superior mesenteric vein thrombosis.
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Shah SR, Gupta AD, Sharma A, Joshi A, Desai D, Abraham P. Acute superior mesenteric vein thrombosis associated with factor V 'Leiden' gene mutation. Journal of the Association of Physicians of India. 2003 Jun; 51(): 611-3