Browsing by Author "Rajkumar, D"
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Item Adenosquamous carcinoma of colon.(2001-11-31) Rajkumar, D; Prakash, A; Arya, S V; Sinha, A NPrimary adenosquamous carcinoma of the colon is an aggressive entity. We report a 41-year-old man with a combination of adenocarcinoma and squamous cell carcinoma of the cecum, treated by right hemicolectomy and ileo-transverse anastomosis. Postoperatively he received adjuvant chemotherapy. However, the tumor recurred at the original site within two months and thereafter the patient was lost to follow up.Item Comparative study of serum iron and zinc levels in term and preterm babies delivered in RMMCH(Educational Society for Excellence, 2018) Malathi, R. Manimozhi; S, Ramesh; Rajkumar, DBackground: Malnutrition is an important factor that influences the course of pregnancy and fetal development. It is a serious international problem which leads to a deficiency of metals, trace elements, vitamins, and proteins. Much attention has been given to the effects associated with protein deficiency. Nowadays the effects due to the deficiency of trace elements have been given much importance. Trace elements are essential for life. Deficient intake- leads to impairment of some functions. The impairment may be corrected by intake of the element in physiological amount. With the deficiency of these elements, the organisms can neither grow nor complete its life cycle. Death of an organism results when there is an absolute deficiency. Aim: To compare serum iron and zinc level in term and preterm babies. Materials and methods: Sixty pregnant women who came from in and around Chidambaram who fulfilled the inclusion criteria during the period from July 2001 to March 2002 were included in this study. Among them, 50 delivered at term (37 to 42 weeks) and the rest delivered prematurely (< 37 weeks). Serum iron and zinc level were estimated by standardized technique. The results are analyzed accordingly. Results: The estimated mean iron value for the term babies was found to be 114.34 μg/dl with the standard deviation of 34 μg/dl. In case of preterm babies, the estimated mean value for iron was found R. Manimozhi Malathi, S. Ramesh, D. Rajkumar. Comparative study of serum iron and zinc levels in term and preterm babies delivered in RMMCH. IAIM, 2018; 5(9): 58-62. Page 59 to be 97.35 μg/dl with the standard deviation of 46 μg/dl. The mean zinc value of term babies was found to be 76.26 μg/dl with the standard deviation of 23 μg/dl. For preterm babies mean zinc value was found to be 56.53 μg/dl with the standard deviation of 29 μg /dl. Conclusion: Preterm birth deprives the fetus of a significant accumulation of iron in storage that occurs beyond 32nd week, total body iron deposits in tissues, Hb and zinc are low in premature babies. Iron deficiency affects perinatal growth, maturation, and function of multiple organ systems including the heart, skeletal muscle, gastrointestinal tract, and brain. Anemia of prematurity has been defined as low hematological constant levels of hemoglobin (Hb), hematocrit (Ht), serum iron, number of erythrocytes, the reticulocytes.Item Morphometry of Human Placenta in Natural Conception and Assisted Reproduction with its Clinical Significance(Society for Health Care & Research Development, 2019) Ananthi, V; Rajkumar, D; Muniappan, VIntroduction:Placenta is a mirror which reflects the antepartum status of fetus in utero. Our present study aimed to analyse the morphometry of placenta in normal and assisted reproduction.Subjects and Methods:30 Placentas of natural conception and 42 placentas of assisted reproduction (18 cases of singleton pregnancies, 12 cases of twin pregnancies) were collected from OG department, Rajah Muthiah Medical College and from private fertility centre in and around Chidambaram immediately after delivery. Morphometric dimensions of placenta like thickness, diameter, area, number of cotyledons were measured placental weight, fetal weight were also measured.Results:Placental weight of natural conception was 489 ± 107.84 grams, 316.78 ± 88.24 grams in assisted reproduction. Thickness of placenta was 2.767 ± 0.68 cm in natural conception, 1.78 ± 0.68 cm in assisted reproduction. Number of cotyledons, fetal weight, feto - placental ratio were also reduced in assisted reproduction.Conclusion:This is the first study to analyse the morphometric dimensions of placenta in natural conception and in assisted reproduction. Overall there was a reduction in all dimensions of placenta in assisted reproduction. This will be useful for pediatricians who handle the newborns of assisted reproduction.Item Protective Effect of Glutathione Against Isoproterenol Induced Myocardial Injury in Rats.(2013-04) Sudha, M; Rajkumar, D; Felix, John WillamsThough there are studies to show protective effect of glutathione against neurotoxicity and nephrotoxicity, the present study was designed to investigate the cardio protective effect of glutathione against isoproterenol induced myocardial infarction in rats by demonstrating the changes in serum cardiac markers, antioxidant enzymes and ECG changes. Wistar male rats were randomly divided into four groups namely control (GI), glutathione (GII), isoproterenol (GIII) and glutathione + isoproterenol treated (GIV). Glutathione treated group-received glutathione (200 mg/kg body wt) orally for 30 days. Myocardial infarction was induced in rats by isoproterenol administration (100mg/kg) subcutaneously (sc) at an interval of 24 hrs on 31st and 32nd day cardiac marker enzymes, ECG, lipid peroxidation and antioxidant enzymes were assessed 24 hrs after the last dose of isoproterenol. Isoproterenol showed changes in ECG pattern, increase in serum level of cardiac marker, increased lipid per oxidation and decreased antioxidant defense system in heart. Glutathione pretreatment brings almost all the parameters to near normal level in isoproterenolinduced myocardial infarction in rats. The present study revealed that glutathione ameliorates cardiac damage in isoproterenol induced myocardial infarction in rats due to potent antioxidant, free radical scavenging effect, myocardial adaptation at cellular and organ levels.