Protective Effect of Glutathione Against Isoproterenol Induced Myocardial Injury in Rats.
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Date
2013-04
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Abstract
Though there are studies to show protective effect of glutathione
against neurotoxicity and nephrotoxicity, the present study was designed
to investigate the cardio protective effect of glutathione against
isoproterenol induced myocardial infarction in rats by demonstrating the
changes in serum cardiac markers, antioxidant enzymes and ECG changes.
Wistar male rats were randomly divided into four groups namely control
(GI), glutathione (GII), isoproterenol (GIII) and glutathione + isoproterenol
treated (GIV). Glutathione treated group-received glutathione (200 mg/kg
body wt) orally for 30 days. Myocardial infarction was induced in rats by
isoproterenol administration (100mg/kg) subcutaneously (sc) at an interval
of 24 hrs on 31st and 32nd day cardiac marker enzymes, ECG, lipid
peroxidation and antioxidant enzymes were assessed 24 hrs after the last
dose of isoproterenol. Isoproterenol showed changes in ECG pattern,
increase in serum level of cardiac marker, increased lipid per oxidation and
decreased antioxidant defense system in heart. Glutathione pretreatment
brings almost all the parameters to near normal level in isoproterenolinduced
myocardial infarction in rats. The present study revealed that
glutathione ameliorates cardiac damage in isoproterenol induced myocardial
infarction in rats due to potent antioxidant, free radical scavenging effect,
myocardial adaptation at cellular and organ levels.
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Keywords
reduced glutathione, myocardial infarction, rats
Citation
Sudha M, Rajkumar D, Felix John Willams. Protective Effect of Glutathione Against Isoproterenol Induced Myocardial Injury in Rats. Indian Journal of Physiology and Pharmacology. 2013 Apr-Jun; 57(2): 132-137.