Browsing by Author "Prasad, D"
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Item Carbon monoxide poisoning.(2001-06-05) Mehta, S R; Niyogi, M; Kasthuri, A S; Dubal, U; Bindra, S; Prasad, D; Lahiri, A KOBJECTIVES: We studied the clinical profile and autopsy findings of carbon monoxide (CO) poisoning encountered at a hospital located at the altitude of 5,000 ft above mean sea level. METHODS: Clinical and postmortem findings in 25 and 15 cases of accidental CO poisoning respectively were evaluated. The diagnosis was made on circumstantial evidences, definite history of "Bukhari" burning and positive Kunkel's test for carboxyhaemoglobin (COHb). Detailed routine investigations including pulse oxymetry, X-ray chest and electrocardiographical monitoring was carried out in all the 25 patients. Oxygen (100%) via an endotracheal tube in all the comatosed patients and by conventional non-rebreathing plastic face masks was the mainstay of treatment. All patients were monitored and followed up for any delayed neurological sequelae. RESULTS: Most of the patients were young adults and the duration of exposure varied between three to eight hours. The initial diagnosis was stroke in three, seizure in one, encephalitis in two and ischaemic heart disease (IHD) in four. Neurological and respiratory signs and symptoms were noted in 19 and 18 of 25 patients respectively. SPO2 measured by pulse oxymetry was normal in all cases. ECG was suggestive of IHD in four patients. No delayed neurological sequelae was noted in any patients. Autopsy revealed deep red discoloration of skin and serous membranes in 80%, pulmonary oedema in 100% and cerebral oedema with widespread multiple pin point haemorrhages mainly in thalamus and globus pallidus in 40%. CONCLUSION: A high level of suspicion and routine history about the kind of indoor heating, specially in cold climate areas during winter will help in early diagnosis and decrease the incidence of misdiagnosis of CO poisoning. Oxygen (100%) or hyperbaric oxygen, if available should be administered without waiting for COHb levels to decrease morbidity and mortality.Item Hyponatremia revisited.(2000-03-07) Narula, A S; Murty, M S; Prasad, DItem Intracranial subfrontal schwannoma treated with surgery and 3D conformal radiotherapy.(2004-06-23) Prasad, D; Jalali, Rakesh; Shet, TSubfrontal schwannoma not arising from the cranial nerves are rare tumors. A 19-year-old man presented with a large subfrontal extra-axial enhancing mass with a preoperative diagnosis of skull base meningioma. A subtotal resection of the tumor mass was carried out. Microscopic examination revealed it to be a schwannoma. The residual tumor was treated with fractionated three-dimensional conformal radiotherapy (3D CRT). The rationale of treating with radiotherapy in such cases is analyzed.Item Septal deviation in neonates.(1989-07-01) Chintapatla, S; Kudva, Y C; Nayar, R C; Raghuveer, T S; Prasad, DDeviated nasal septum (DNS) is believed to occur in neonates following the trauma of birth processes. The present prospective study was undertaken to evaluate the relationship of intrauterine and parturition processes with neonatal septal dislocations. The neonates were subjected to a series of tests to assess presence and extent of deviated septum within the first 48 hours. A statistically significant correlation was demonstrable between the incidences of septal deviations with intra uterine fetal positions and mode of delivery.Item Wound healing profiles of ketorolac, metronidazole and tinidazole administered post-surgically.(1995-11-01) Prasad, D; Rao, C MOn dead space wounds, drugs (ketorolac, metronidazole and tinidazole) caused a significant (P < 0.01) decrease in breaking strength, granulation tissue weight and hydroxyproline content in male rats. Both the parameters of excision wound were significantly (P < 0.01) hastened by metronidazole and tinidazole only. Post operative management of wounds with ketorolac (a potent analgesic), metronidazole and tinidazole (for anaerobic infections) may be dealt with the risk of a delay in healing. Both metronidazole and tinidazole promote the epithelization process.