Browsing by Author "Pawar, P"

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    Cherubism in siblings: A case report.
    (2007-03-26) Sarda, D; Kothari, P; Kulkarni, B; Pawar, P
    Cherubism is a benign disease of bones affecting the jaws and giving a characteristic cherubic appearance to the patient. On radiography, the lesions exhibit bilateral multilocular radiolucent areas. Histopathology shows numerous multinucleated giant cells in the background of proliferating fibrous connective tissue. Cherubism can be a solitary case. The present report describe cherubism in two siblings and briefly review the literature on this subject.
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    Correlation of glycated haemoglobin( HbA1c) with TNF-? and Oxidised-LDL in Type 2 DM
    (?Eldaghayes Publisher, 2024-12) Pawar, P; Dhama, A; Chahal, A; Ghalaut, VS.
    Background: Type 2 diabetes mellitus (DM) is rising as a major health concern worldwide. The pathogenesis of DM and its complications involve an array of dynamic interactions between genes, inflammatory cytokines like TNF-?, oxidative stress, environmental factors, and lifestyle. Several studies have shown a strong correlation of Ox-LDL (Ox- idized low-density lipoprotein) and TNF-? (tumor necrosis factor-?) with IR (insulin resistance). Hence, the present study was designed to study the correlation between HbA1c (glycated hemoglobin) (a marker of glycemic control) with TNF-? (a marker of chronic inflammation) and Ox-LDL (a marker of oxidative stress). Aim and objectives: To study the correlation between TNF-? and Ox-LDL with HbA1c in Type 2 DM. Methods: For our pilot study, we recruited patients with type 2 DM belonging to the age group 35-50 years of either gender from Medicine OPD as cases. The institutional ethics committee approval has been taken before commence- ment of the study. After informed consent from patients, venous blood samples were collected and analyzed using a biochemistry autoanalyzer and appropriate ELISA kit. Data were analyzed statistically using SPSS software. Result: The study showed raised levels of HbA1c, TNF-?, and OX-LDL in type 2 DM patients. Conclusion: Furthermore, a significant positive correlation was observed between TNF-? and HbA1c (r = 0.829) and also between Ox-LDL and HbA1c (r = 0.638).
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    Developmental inhibition and reproductive potential impairment in Musca domestica L. by heavy metals.
    (2001-01-15) Raina, R M; Pawar, P; Sharma, R N
    Post embryonic development and adult emergence of housefly, M. domestica L. was adversely affected in varying degrees on exposure of larvae to 6 different heavy metals. Of these, salts of mercury, aluminium and cadmium exhibited significant reduction in normal adult emergence. High decline in reproductive potential in terms of female fecundity and egg hatchability was also observed in the F1 progenies of treated larvae. The results are discussed in light of heavy pollution of environment by such contaminants.
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    Metastatic tumors to the jaw bones: Retrospective analysis from an Indian tertiary referral center.
    (2011-04) Muttagi, S S; Chaturvedi, P; D'Cruz, A; Kane, S; Chaukar, D; Pai, P; Singh, B; Pawar, P
    Aim: Being a tertiary referral center, we encounter the highest number of oral cancer patients in India, and there is direct involvement of the jaw bone in approximately 40% of these cases. There are no large case series from the Indian subcontinent on metastatic tumors to the jaw bones. With this retrospective analysis, we intend to estimate the incidence of this rare manifestation in the jaw bones in our patients and compare it with the available literature. Materials and Methods: All patients with biopsy proven metastatic disease involving jaw bones having complete clinical data were included. Results: Nineteen out of 10,411 oral cancer patients who reported between the years 2000 and 2005 were included. Breast and thyroid malignancies (5/19 each) were commonest in the females to metastasize to the mandible, whereas in the males, there was no predominant site that resulted in jaw bone metastasis, although mandible was commonly affected. Neuroblastoma of adrenal gland metastasized to maxilla in the age group ranging from 4 months to 16 years. Maxilla was the commonest jaw bone affected in this age group. In five cases, jaw bone was found to be the first site of metastasis. Conclusions: There is variation in the primary site that causes metastasis to the jaw bones depending on age, sex and geographic distribution. Jaw bone metastases are rare and can be the first site of metastasis. We get approximately four cases in a year with metastatic disease manifesting in the jaw bones. Metastasis to jaw bone is associated with poor prognosis.
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    An observational study of predictive factors for fever and sepsis following percutaneous nephrolithotomy
    (Medip Academy, 2024-03) Pratap, V; Sayed, AA; Kharade, M; Pawar, P; Sawant, A; Ahmed, MHS; Shewale, R; Trivedi, U; Dange, S; Dalvi, J; Chiddarwar, A; Chaudhari, S
    Background: Although percutaneous nephrolithotomy is considered a safe procedure, it is not without complications. Certain preoperative and intraoperative factors if not identified and adequately treated in time can lead to complications ranging from post operative fever to urosepsis which may seldom lead to mortality. The aim of our study is to identify those factors so as to prevent complications and promote patient safety. Methods: Retrospective analysis of medical records of the patients undergoing PCNL from January 2020 to January 2023 was done. A total of 235 patients were included in the study and associated factors analyzed statistically. Statistical analysis was performed by Chi-square test. Results: We found five factors which significantly correlated with postoperative sepsis, namely, stone size >30 mm, staghorn calculus, prolonged operative time >120 min, significant bleeding requiring transfusion and pre operative urine culture positive. Conclusions: Sepsis following PCNL is not uncommon. Progression to urosepsis maybe life threatening. Decreasing operative time decreases bleeding and related complications as well. Prophylactic antibiotics is recommended in PCNL procedure owing to its clean contaminated/contaminated surgical procedure.
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    A review of Indian literature for association of smokeless tobacco with malignant and premalignant diseases of head and neck region.
    (2014-07) Datta, S; Chaturvedi, P; Mishra, A; Pawar, P
    In India, about 60% of tobacco users use smokeless tobacco (ST) alone. Head and neck squamous cell carcinoma is one of the most common cancers in India. International Agency for Research on Cancer (IARC) monograph (Vol 89) found a significant association between ST use and oral cancer. However, only a few articles from India were included in this monograph. To overcome this lacuna, we have reviewed the articles published from India investigating the association between ST use and malignant and premalignant diseases of head and neck region. Data collection has been performed by computer-aided search of the MedLine and PubMed databases using different combinations of the key words. For malignant lesions, only cohort and case control studies were considered for review. For premalignant lesions and dental diseases other than case control studies, some cross-sectional studies have also been reviewed. Studies found a significant association between ST use and cancer of the oral cavity. The association was stronger for the buccal mucosa compared to tongue and for females compared to males. Significant association noted between cancer of the hypopharynx and oropharynx with ST use but no definitive association noted for cancer of the larynx and nasopharynx. Some dental disease and oral premalignant conditions were also associated with ST use. Indian studies suggest ST use is strongly associated with cancer of the oral cavity, oropharynx and hypopharynx.