Browsing by Author "Parikh, E H"

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    A case of acute myeloid leukemia-M2 with trisomy 4 in addition to t(8;21).
    (2008-01) Trivedi, P J; Patel, P S; Brahmbhatt, M M; Patel, B P; Gajjar, S B; Iyer, R R; Parikh, E H; Shukla, S N; Shah, P M; Bakshi, S R
    t(8;21)(q22;q22) is the most frequently observed karyotypic abnormality associated with acute myeloid leukemia (AML), specifically in FAB-M2. Short-term unstimulated bone marrow (BM) and peripheral blood lymphocyte culture showed 47,XX, +4,t(8;21) in all metaphase plates; and interphase and metaphase results of AML-ETO fusion was positive and trisomy of 4 was confirmed with WCP probes. Trisomy 4 in AML with t(8;21) is a rare numerical abnormality. Here we present such case of patient which may constitute a distinctive subtype.