Browsing by Author "Mohanty, J"

Now showing 1 - 7 of 7
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    Comparing Oral Tranexamic Acid and Q-Switched Nd-YAG Laser for Melasma: A Randomized Study
    (Society for Scientific Research, 2024-01) Khan, AS; Sathyanath, A; Kurian, AM; Mohanty, P; Bisoyi, D; Mohanty, J; Dash, M
    Background: Addressing the challenges of limited therapeutic options for melasma, this study explores the novel approach of combining oral Tranexamic acid with Q switched Nd-YAG laser. The aim is to evaluate the efficacy of this combination against oral Tranexamic acid (TNA) alone in treating melasma. Method: This study was conducted as a prospective, randomized, open-label study with a sample size of 50, Group A (25 patients) received oral Tranexamic acid along with Nd-YAG laser treatment every 15 days for 3 months. Group B received only oral Tranexamic acid for the same duration. Clinical photographs were taken at each session, and patients were followed up for 3 and 6 months. Result: The study found a 49.96% mMASI change in Group A and a 38.74% change in Group B after 3 months. Both groups exhibited similar percentages of reversal, with the combination group showing a marginally higher percentage. However, the difference was statistically insignificant (p=0.55). A limitation of the study was its small sample size. Conclusion: The combination therapy demonstrated better responses for both mixed and dermal melasma types. Notably, laser treatment alone did not yield significant outcomes and carried a higher risk of hyperpigmentation, making it unsuitable for treating epidermal melasma
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    Efficacy of itraconazole in the treatment of tinea versicolor.
    (2001-09-01) Mohanty, J; Sethi, J; Sharma, M K
    Twenty adult patients (15 males and 5 females) with extensive, clinically diagnosed tinea versicolor (TV.) resistant to topical agents, of long duration were selected. Laboratory investigations like KOH smear, routine haemogram, LFT, and RFT were done. They were given itraconazole (100 mg) orally twice daily for 5-7 days and followed up at the end of 1 week and again three weeks later. After one week itching, erythema and scaling subsided in 80% of cases. There was no recurrence during one year follow up.
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    Epidermal cyst.
    (1974-01-16) Chandra, K; Mohanty, J
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    Isolated Nerve Sheath Tumor Of Jejunum Presenting As Acute Abdomen.
    (2013-01) Mohanty, J; Prasad, S
    Nerve sheath tumors of gastrointestinal tract are rare and occurs more frequently as systemic manifestations of generalized neurofibromatosis type-1(NF-1).In neurofibromatosis-1 lesions may be scattered or solitary tumor. Occasionally ,such tumors may be the initial presenting feature of NF-1.Rarely ,cases of isolated nerve sheath tumor of small intestine presenting with bleeding and obstruction have been documented. We report a 19years male presenting with nerve sheath tumor of jejunum in acute abdomen. His investigations show no features of NF-1.
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    Pyoderma gangrenosum.
    (2003-03-24) Devi, B; Mohanty, J
    Four patients aged 8, 35, 45 and 50 years (3 males and 1 female) were admitted to SCBMCH, Cuttack, skin and VD Department with multiple, painful, non healing phagadenic ulcers over body and not responding to the conventional therapeutic agents. The female patient was having severe seropositive rheumatoid arthritis. Pus culture was negative in all the cases. All the patients responded well to corticosteroid given systemically, but one male patient was having recurring episodes and ulcers healing hardly. He was given topical oxoferrin (TCDO) topically twice daily along with other supportive therapy. He responded well.
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    A Randomised Open Label Trial to Evaluate the Efficacy of TCA Peel with Oral Metformin vs TCA Peel with Oral Alpha Lipoic Acid in Acanthosis Nigricans
    (Society for Scientific Research, 2024-03) Das, M; Mohanty, J; Mohapatra, S; Mashrani, K; Das, K; Dash, M; Bisoyi, D
    Background: Acanthosis Nigricans (AN) is a condition acquired by keratinization. It presents as velvety skin and hyperpigmentation and can affect any area of the body, including the face. Several topical, systemic, and physical therapies, including laser therapy have been studied. For the most part, randomised controlled trials are lacking for therapy choices other than weight loss and lifestyle adjustments. Therefore, the present study was designed to compare the efficacy of 15% trichloroacetic acid (TCA) peel with oral metformin against 15% TCA peel with alpha lipoic acid in cases of AN with metabolic syndrome. Methods: Fifty patients were included & divided into two groups. Each patient in Group A was given oral alpha lipoic acid 200 mg BID along with monthly 15% TCA for 03 months, while in Group B, patients were given monthly oral metformin 500 mg BID for three months along with monthly 15% TCA. The effectiveness of each peel was assessed by looking into the severity of neck lesions & texture. Results: The generalized estimating equations method was used to compare the total change over time in the two groups. Over time, there was a substantial difference between the two groups (p<0.001). When compared to a TCA peel with an oral lipoic acid group, the skin thickness and texture changed more in the metformin group. Conclusion: In both groups, oral metformin with TCA peel was more effective than oral alpha lipoic acid in our study. As a safe and efficient treatment for AN, we advise using metformin in conjunction with a 15% TCA peel. For supporting data, however, more thorough randomized control studies are needed.
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    Study of Efficacy of Radiofrequency Cautery in Treatment of Xanthelasma
    (Society for Scientific Research, 2024-01) Bisoyi, D; Khan, AS; Puhan, MR; Mohanty, P; Lenka, S; Mohanty, J
    Background- Xanthelasma is a most common xanthoma presented clinically as a yellowish oval papule and plaques over and around periorbital region. Only from cosmetic point of view do patients need to remove these lesions. Our study aimed to evaluate the efficacy of radiofrequency cauterization as a treatment modality in xanthelasma. Methods- It is a prospective interventional study in which 40 patients with 114 lesions were included. Radiofrequency (RF) cautery was done after local anaesthesia is given. The study was conducted from August 2013 to August 2014 at a tertiary care hospital. Before and after therapy, pictures were taken, and patients were checked on every four to six weeks. Result: Forty patients with 114 xanthelasma lesions were included in the study. The patients were mostly in their fourth or fifth decade, with ages ranging from 29 to 62. In the study group, the male to female ratio was 1:2. Xanthelasma was most commonly found over the inner and upper eyelids, followed by the outer and lower eyelids. Bilateral involvement was seen in most cases. The majority of patients were classified as grade-3, indicating xanthelasma over the medial side of the upper and lower eyelids. Conclusion- RF cauterization is a cost-effective xanthelasma palpebrarum treatment with a lower recurrence rate. It's safe, minimally complication-prone, and often associated with underlying plasma lipid disease. Despite its potential, there's no approved long-term treatment alternative. RF cauterization is convenient for dermatologists.