Comparing Oral Tranexamic Acid and Q-Switched Nd-YAG Laser for Melasma: A Randomized Study
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Date
2024-01
Journal Title
Journal ISSN
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Publisher
Society for Scientific Research
Abstract
Background: Addressing the challenges of limited therapeutic options for melasma, this study explores the novel approach of combining oral Tranexamic acid with Q switched Nd-YAG laser. The aim is to evaluate the efficacy of this combination against oral Tranexamic acid (TNA) alone in treating melasma. Method: This study was conducted as a prospective, randomized, open-label study with a sample size of 50, Group A (25 patients) received oral Tranexamic acid along with Nd-YAG laser treatment every 15 days for 3 months. Group B received only oral Tranexamic acid for the same duration. Clinical photographs were taken at each session, and patients were followed up for 3 and 6 months. Result: The study found a 49.96% mMASI change in Group A and a 38.74% change in Group B after 3 months. Both groups exhibited similar percentages of reversal, with the combination group showing a marginally higher percentage. However, the difference was statistically insignificant (p=0.55). A limitation of the study was its small sample size. Conclusion: The combination therapy demonstrated better responses for both mixed and dermal melasma types. Notably, laser treatment alone did not yield significant outcomes and carried a higher risk of hyperpigmentation, making it unsuitable for treating epidermal melasma
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Keywords
Melasma, Tranexamic Acid, TNA, Q switched Nd-YAG Laser, Laser Therapy
Citation
Khan AS, Sathyanath A, Kurian AM, Mohanty P, Bisoyi D, Mohanty J, Dash M. Comparing Oral Tranexamic Acid and Q-Switched Nd-YAG Laser for Melasma: A Randomized Study. SSR Institute of International Journal of Life Sciences. 2024 Jan; 10(1): 3590-3598