Browsing by Author "Dutta, U"

Now showing 1 - 18 of 18
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    Arthritis in hypogammaglobulinemia.
    (1998-04-15) Salaria, M; Singh, S; Dutta, U; Sehgal, S; Kumar, L
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    Blister pack ingestion resulting in esophago-pleural fistula.
    (2001-03-18) Dutta, U; Gupta, N M; Nagi, B; Singh, K
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    Common variable immunodeficiency in an adult.
    (2000-07-23) Wanchu, A; Sud, A; Bambery, P; Singh, S; Dutta, U; Varma, S
    Primary immunodeficiency syndromes are rarely diagnosed among adults. In this report, we describe a young male who had common variable immunodeficiency. He was treated with intravenous immunoglobulin and, on follow up, has been free of opportunistic infections.
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    Development and Quality Evaluation of Fibre Enriched Broken Basmati Rice Based Noodles
    (Ms. M. B. Mondal, 2024-09) Bandral, JD; Sood, M; Gupta, N; Dutta, U; Choton, S; Chauhan, J.
    Broken rice is fragmented but it cannot be considered as defective because it has same nutritional value as unbroken rice contains. Also, if the broken rice contains all germ and bran, then it has nutrition as brown rice, otherwise it has nutrition as white rice. In the present investigation, protein and fiber rich noodles were prepared by incorporation of groundnut meal (GM) and green leaf powder (GLP) prepared using fenugreek leaves and coriander leaf powder in the ratio 50:50. The quantity of GM and GLP was varied from 0 to 12 and 0 to 18 per cent, respectively for the formulation of rice noodles. The developed products were stored for 90 days in polyethylene bags to ascertain the changes in cooking characteristics, proximate composition and sensory parameters. Weight increase and volume increase showed an increasing trend with the incorporation of green leaf powder and groundnut meal from 142.89 to 183.52 % and 144.73 to 218.98 %, respectively whereas the cooking time and cooking loss significantly decreased from 12.10 to 10.77 minutes and 7.23 to 6.31 per cent, respectively. On the basis of sensory evaluation, noodles prepared from 8 per cent GLP and 12 per cent GM were adjudged the best with regard to their acceptability and storability having mean crude protein, crude fat, crude fibre and ash contents of 17.46, 2.00, 2.17 and 1.01 per cent, respectively.
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    Double blind controlled trial of effect of cisapride on gastric emptying in diabetics.
    (1999-07-01) Dutta, U; Padhy, A K; Ahuja, V; Sharma, M P
    AIMS: Diabetic gastroparesis is a common complication seen in 20-50% of patients due to autonomic neuropathy involving vagal supply. Cisapride, a specific gastrointestinal cholinomimetic agent may thus be effective. METHODS: Fifty-one diabetic patients (age 12-65 years) of disease duration > 5 years were assessed for symptomatic gastroparesis, other diabetic complications and glycemic control. Gastric emptying time (GET) was estimated using a solid meal method (99mTc labeled rice based idli) and patients randomized to receive either cisapride or placebo for a period of 2 weeks. Cisapride was administered in a dose of 10 mg TID. GET and symptom scores were reassessed on the therapy after 2 weeks. RESULTS: Twenty nine of 51 (56.8%) patients had gastroparesis. Mean GET in the gastroparesis group was 141 +/- 66 minutes compared to 24.53 +/- 10 minutes in the non gastroparesis group (p < 0.01). GET decreased by 72% amongst the patients who received cisapride compared to 23% in the placebo group (p < 0.001). Symptom scores also improved in the cisapride group; no adverse effects were noted. CONCLUSIONS: Cisapride improves the symptom score and the solid gastric emptying time in patients suffering from diabetic gastroparesis.
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    Endocrine cell carcinoma of gall bladder.
    (2001-05-13) Bhutani, V; Dutta, U; Nagi, B; Nijhawan, R; Singh, K
    Primary neuroendocrine carcinoma of the gall bladder is rare. We report a 70-year-old woman with a gall bladder mass and liver metastases; fine-needle aspiration cytology from these revealed neuroendocrine carcinoma. There was no evidence of any other primary site. The patient was treated symptomatically; she died within a month of discharge from hospital.
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    Evaluation of Lakadong turmeric derived curcumin nanogel against resistant biofilms: In-silico, antibacterial and antibiofilm analysis
    (Open Science Publishers LLP, 2024-09) Sarma, SK; Dutta, U; Das, BK; Bharali, A; Laloo, D; Kalita, JM; Sahu, BP
    The emergence of drug resistance can lead to increased mortality and morbidity as treatment efficacy declines, and there is an urgent need to explore novel antibacterial compounds with enhanced effectiveness against drugresistant bacteria, particularly resistant biofilms. Curcumin, with its antimicrobial activity, can be a potential safe agent; however, studies on its efficacy against resistant biofilm are limited. This study, therefore, aims to explore the potential of curcumin and/or its novel derivatives against a spectrum of resistant biofilm-related pathogens, including bacteria, fungi, and human pathogens. Another study objective is to investigate the effectiveness of the high-yielding Lakadong turmeric (LKD)-derived curcumin for its antibacterial effects and the ability to inhibit biofilm formation in Gram-positive and Gram-negative bacteria using in-vitro assays. A molecular docking study was used to select the most potential binding interaction between the selected protein structure and ligand molecule for the potential efficacy of curcumin against resistant biofilms. Lakadong-derived curcumin-loaded nano gels (LKD-Cur Nanogel) were prepared and tested for antibacterial (zone-inhibition) and biofilm formation (scanning confocal microscope) activity against Staphylococcus aureus and Pseudomonas aeruginosa. Furthermore, Curcumin derivatives were studied in-silico for potential effectiveness against a spectrum of resistant biofilms. The in-silico results showed that curcumin and/or its novel derivatives exhibited high selectivity toward a range of targeted proteins compared to curcumin. Moreover, LKD-Cur Nanogel exhibited significant anti-bacterial activity with an increased mean zone of inhibition compared to positive control. The biofilm formation assay illustrated that LKD-Cur Nanogel effectively disrupted established bacterial biofilms (both for P. aeruginosa and S. aureus) grown on microtiter plates at a concentration of 1,000 µg/ml compared to the control. Therefore, it can be concluded that curcumin and/or its newly modified derivatives could hold promising antibacterial activity targeting diverse biofilm-associated pathogens based on the in-silico and in-vitro study. Moreover, it can be concluded that LKD-derived curcumin nanogels have good antibacterial and antibiofilm efficacy.
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    Gratitude, Life Satisfaction And Forgiveness Among Acid Attack Victims: Rehabilitation Through Three Good Things Intervention.
    (Light House Polyclinic, 2022-09) Dutta, U; Teotia, A.
    Violence against women is mostly done to show the dominance of the males over the females. Among the various forms of violence, acid attack has been a least researched area. The victims of acid attack are left with scars that they have to carry with them forever, and this leads them to unending trauma and physical pain. In this study, pre-assessment scores were taken from 25 acid attack survivors on the scales of gratitude, life satisfaction and forgiveness. An intervention was carried out with them, where they were asked to keep a daily-dairy, noting down 3-good things that happened to them during the day. After the 14th day, post-assessment scores were taken. Results showed that there was significant correlation between gratitude, life satisfaction and forgiveness in the post-assessment scores. There was also significant increase in the mean score of all the variables. These findings provide evidence for showing that gratitude intervention is effective in increasing the gratefulness, life satisfaction and forgiveness among the acid attack victims, despite their trauma and pain. This study involved a small, difficult-to-reach and often ignored sample. Moreover, implications for the effective use of this intervention with trauma survivors have been discussed.
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    Hemophagocytic syndrome as the presenting manifestation of visceral leishmaniasis.
    (2002-06-21) Bhutani, V; Dutta, U; Das, Reena; Singh, K
    Hemophagocytosis in visceral leishmaniasis is rare and usually mild. However, presentation as hemophagocytic syndrome is exceptionally rare. We report the case of a 28 years man who presented with fever, hepatosplenomegaly, pancytopenia, reactive histiocytes and severe hemophagocytosis. Subsequent investigations revealed he had Leishmania donovani infection.
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    Hypogammaglobulinemia.
    (1984-08-01) Venkateswarlu, K; Malik, A K; Bhasin, D K; Dutta, U; Vinayak, V K; Mehta, S
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    Immunological response in Indian kala-azar.
    (1979-10-01) Aikat, B K; Pathania, A G; Sehgal, S; Bhattacharya, P K; Dutta, U; Pasricha, N; Singh, S; Parmar, R S; Sahaya, S; Prasad, L S
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    Pleural involvement by Salmonella senftenberg: a report of two cases.
    (2000-01-14) Ramanathan, R M; Aggarwal, A N; Dutta, U; Ray, P; Singh, K
    Non-typhoidal serovars of salmonella are an unusual cause of pleuropulmonary infections. We report two patients with empyema caused by Salmonella senftenberg. One patient had associated diabetes and gall bladder carcinoma, and infection was acquired in hospital. Both patients responded well to parenteral antibiotics.
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    Pneumobilia--clue to an unusual cause of diarrhea.
    (2002-07-16) Dutta, U; Nagi, B; Kumar, A; Vaiphei, K; Wig, J D; Singh, K
    A 65-year lady presented with diarrhea and weight loss of six months duration. Initial evaluation suggested that malabsorption was the possible underlying mechanism for the diarrhea. Work up for the common etiologies of malabsorption was non-contributory. Presence of pneumobilia raised the suspicion of a bilio-enteric fistula, which was subsequently confirmed on barium enema and endoscopic cholangio-pancreaticography to be a cholecystocolic fistula. At surgery, a fistulous tract from the fundus of the gallbladder was found to be communicating with the hepatic flexure. Fistulectomy with cholecystectomy resulted in prompt relief of symptoms. Cholecystocolic fistula (CCF) is a rare biliary fistula with diverse presentation.
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    A prospective study on the incidence of hepatitis B & C infections amongst patients with lymphoproliferative disorders.
    (1998-02-16) Dutta, U; Raina, V; Garg, P K; Gurbuxani, S; Joshi, Y K; Bhargava, M; Tandon, R K
    Fifty one patients with acute lymphoblastic leukaemia (ALL) and non-Hodgkins lymphoma (NHL) undergoing chemotherapy were studied prospectively to determine the incidence, aetiology and natural course of hepatitis. Of 51 patients (31 NHL and 20 ALL), 22 developed hepatitis. Hepatitis B (IgM anti HBc positive) was the cause in 11 patients (50%), hepatitis C in 4 patients, and septicaemia and cytotoxic drugs in 3 patients each. Malignant infiltration of the liver was the cause in the remaining 1 patient. Hepatitis was predominantly (75%) anicteric. Mean duration of hepatitis was 21 days. Of 51 patients, 21 acquired hepatitis B and/or C virus infection. They had received 6.4 (+/- 3.4) units of packed red cells and 5.3 (+/- 11) units of platelet concentrate as compared to 3.4 (+/- 4.8) units of red cells and 5.3 (+/- 12.1) units of platelet concentrate received by those who did not acquire virus infection (P < 0.05 for packed red cells). Only transient stoppage of chemotherapy was necessary following development of hepatitis and most of the patients who developed hepatitis could complete their chemotherapy schedule. None of the patients who developed viral B or C infection cleared the infection. We conclude that there was a high incidence of hepatitis B and C infection amongst patients with lymphoproliferative disorders with an increased carrier rate. Transfusion was a major risk factor for such infections.
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    Reversible portal hypertension due to tuberculosis.
    (2000-07-05) Dutta, U; Bhutani, V; Nagi, B; Singh, K
    Presentation of abdominal tuberculosis with portal hypertension is rare. We report a 25-year-old man with portal hypertension due to compression of the portal vein by tuberculous lymph nodes at the hepatic hilum. After antitubercular therapy, features of portal hypertension disappeared as the nodes regressed.
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    Severe acute bleeding from portal colopathy controlled by somatostatin: a case report.
    (2004-07-03) Rana, S S; Dutta, U; Sinha, S K; Kochhar, R; Nagi, B; Bhasin, D K
    Portal hypertensive colopathy (PHC) is a recently described entity in patients with portal hypertension which can cause even life-threatening lower gastrointestinal bleeding. In contrast to variceal bleed, there is no standardized treatment for the control of bleeding from these lesions. We report a case of alcoholic cirrhosis with portal hypertension, in whom bleeding from colonic angiodysplasia-like lesions was effectively controlled by somatostatin infusion.
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    Severe duodenal candidiasis in a patient with IgA deficiency and T cell defects.
    (1990-01-01) Singh, S; Kochhar, R; Dutta, U
    Candida albicans was found to repeatedly colonise and invade the duodenal ulcer base in a 45 years old otherwise healthy patient receiving H2 receptor antagonists for a prolonged period. He had no delayed hypersensitivity to Candida skin test, and had T cell deficiency, abnormality in T cell blast transformation, defective macrophage migration inhibition factor (MIF) and IgA hypogammaglobulinemia. When treated with ketoconazole alone his ulcer healed completely. Ulcer scar biopsy and aspirates revealed no Candida and anti candidal antibodies disappeared from his serum. His T cell blastoid transformation, MIF and skin DTH to Candida were restored to normal levels, but IgA levels remained unchanged. Thus H2 receptor antagonists probably caused abnormalities in T helper cells leading to lymphokine unresponsiveness and subsequently loss of cellular immunity to candidal antigen. This combined with prior IgA immunodeficiency resulted into severe invasive candidiasis.